Dual stimuli-responsive polymeric hollow nanocapsules as "smart" drug delivery system against cancer

被引：27

作者：

Jahanban-Esfahlan, Rana ^{[1
]}

Massoumi, Bakhshali ^{[2
]}

Abbasian, Mojtaba ^{[2
]}

Farnudiyan-Habibi, Amir ^{[3
,4
]}

Samadian, Hadi ^{[5
]}

Rezaei, Aram ^{[5
]}

Derakhshankhah, Hossein ^{[6
]}

Jaymand, Mehdi ^{[5
]}

机构：

[1] Tabriz Univ Med Sci, Sch Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran

[2] Payame Noor Univ, Dept Chem, Tehran, Iran

[3] Univ Tehran Med Sci, Dept Pharmaceut Biomat, Fac Pharm, Tehran, Iran

[4] Univ Tehran Med Sci, Med Biomat Res Ctr, Fac Pharm, Tehran, Iran

[5] Kermanshah Univ Med Sci, Hlth Technol Inst, Nano Drug Delivery Res Ctr, Kermanshah, Iran

[6] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran

来源：

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS | 2020年 / 59卷 / 13期

关键词：

Nanomedicine; cancer chemotherapy; hollow nanocapsules; stimuli responsive; RADICAL POLYMERIZATION; NANOPARTICLES; COMBINATION; FORMULATION;

D O I：

10.1080/25740881.2020.1750652

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel thermal- and pH-responsive hollow nanocapsules (HNCaps) were fabricated through the grafting of a thiol-end capped PNIPAAm-b-PAA by thiol-ene "click" reaction onto PMMA HNCaps. The lowest critical solution temperature (LCST) of the fabricated HNCaps was obtained as 38-40 degrees C. The fabricated nanosystem was loaded with doxorubicin hydrochloride (Dox), and its drug loading and encapsulation efficiencies were obtained as 62 and 53%, respectively. The in vitro stimuli-responsive drug release behavior of the fabricated nanomedicine was investigated extensively. The anticancer activity of the drug-loaded HNCaps was evaluated using MTT assay against MCF7 cells. The results exhibited excellent potential of nanosystem as a drug delivery system (DDS) for cancer chemotherapy.

引用

页码：1492 / 1504

页数：13

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