Decreased regional cerebral blood flow in patients with diphenylarsinic acid intoxication

被引：1
作者：
Ishii, K. [1 ]
Nemoto, K. [2 ]
Iwasaki, N. [3 ]
Takeda, T. [4 ]
Masuda, T. [1 ,5 ]
Shibata, Y. [6 ]
Tamaoka, A. [1 ]
机构：
[1] Univ Tsukuba, Fac Med, Dept Neurol, 1-1-1 Tennnoudai, Tsukuba, Ibaraki 3058575, Japan
[2] Univ Tsukuba, Dept Psychiat, Fac Med, Tsukuba, Ibaraki, Japan
[3] Ibaraki Prefectural Univ Hlth Sci, Dept Pediat, Ami, Ibaraki, Japan
[4] Kitasato Univ, Allied Hlth Sci, Sagamihara, Kanagawa, Japan
[5] Univ Tsukuba, Dept Neurobiol, Fac Med, Tsukuba, Ibaraki, Japan
[6] Natl Inst Environm Studies, Ctr Environm Measurement & Anal, Tsukuba, Ibaraki, Japan
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 2019年 / 26卷 / 01期
基金：
日本学术振兴会;
关键词：
cerebral blood flow; diphenylarsinic acid intoxication; single-photon emission tomography; GLUTAMINASE-C; DEGRADATION; RELEASE;
D O I：
10.1111/ene.13783
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background and purpose Diphenylarsinic acid (DPAA) intoxication caused by drinking contaminated well water was found in Kamisu, Japan. The symptoms indicated cerebellar-brainstem and temporo-occipital involvement. However, it remains unclear how it affects the human brain. To elucidate the effect of DPAA on the human brain, we analyzed cerebral blood flow (CBF) data after the drinking of DPAA-contaminated water was stopped and investigated the correlation between DPAA exposure level and CBF by single-photon emission computed tomography (CBF-SPECT). Methods The DPAA-exposed inhabitants (n = 78) were divided into 35 symptomatic and 43 asymptomatic subjects and compared with 38 healthy controls. The DPAA concentration in nails or hair and well water was measured using a high-performance liquid chromatography system and coupled plasma mass spectrometry after adequate extraction treatment. CBF-SPECT data, obtained within 1 year after the drinking of contaminated well water was stopped, were analyzed by statistical parametric mapping. We also examined the relationship between variations in CBF-SPECT signals and variations in DPAA concentrations in the hair or nails of the subjects. Results Compared with control subjects, CBF in symptomatic DPAA-exposed subjects was significantly lower in the occipital lobe, including the cuneus and inferior occipital gyri. The DPAA concentration in the nails or hair of subjects was inversely and significantly related to their CBF. Conclusion These data suggest that CBF-SPECT may be useful as a clinical marker to infer the effect of accumulated DPAA on the brain.
引用
收藏
页码：136 / 141
页数：6
相关论文
共 12 条
[1]   Methylmercury poisoning in common marmosets - A study of selective vulnerability within the cerebral cortex [J].
Eto, K ;
Yasutake, A ;
Kuwana, T ;
Korogi, Y ;
Akima, M ;
Shimozeki, T ;
Tokunaga, H ;
Kaneko, Y .
TOXICOLOGIC PATHOLOGY, 2001, 29 (05) :565-573
[2]   Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan [J].
Ishii, K ;
Tamaoka, A ;
Otsuka, F ;
Iwasaki, N ;
Shin, K ;
Matsui, A ;
Endo, G ;
Kumagai, Y ;
Ishii, T ;
Shoji, S ;
Ogata, T ;
Ishizaki, M ;
Doi, M ;
Shimojo, N .
ANNALS OF NEUROLOGY, 2004, 56 (05) :741-745
[3]   Detection of diphenylarsinic acid and its derivatives in human serum and cerebrospinal fluid [J].
Ishii, Kazuhiro ;
Itoh, Yasunori ;
Iwasaki, Nobuaki ;
Shibata, Yasuyuki ;
Tamaoka, Akira .
CLINICA CHIMICA ACTA, 2014, 431 :227-231
[4]   Urine analysis of patients exposed to phenylarsenic compounds via accidental pollution [J].
Kinoshita, Kenji ;
Noguchi, Ayano ;
Ishii, Kazuhiro ;
Tamaoka, Akira ;
Ochi, Takafumi ;
Kaise, Toshikazu .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2008, 867 (02) :179-188
[5]   Down-regulation of glutaminase C in human hepatocarcinoma cell by diphenylarsinic acid, a degradation product of chemical warfare agents [J].
Kita, Kayoko ;
Suzuki, Toshihide ;
Ochi, Takafumi .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2007, 220 (03) :262-270
[6]   Diphenylarsinic Acid Promotes Degradation of Glutaminase C by Mitochondrial Lon Protease [J].
Kita, Kayoko ;
Suzuki, Toshihide ;
Ochi, Takafumi .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (22) :18163-18172
[7]   Distribution and excretion of arsenic in cynomolgus monkey following repeated administration of diphenylarsinic acid [J].
Kobayashi, Yayoi ;
Negishi, Takayuki ;
Mizumura, Ayano ;
Watanabe, Takayuki ;
Hirano, Seishiro .
ARCHIVES OF TOXICOLOGY, 2008, 82 (08) :553-561
[8]   Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys [J].
Masuda, Tomoyuki ;
Ishii, Kazuhiro ;
Seto, Yasuo ;
Hosoya, Tomoko ;
Tanaka, Ryuta ;
Nakayama, Tomohiro ;
Iwasaki, Nobuaki ;
Shibata, Yasuyuki ;
Tamaoka, Akira .
ARCHIVES OF TOXICOLOGY, 2017, 91 (08) :2799-2812
[9]   Dysregulation of MAP Kinase Signaling Pathways Including p38MAPK, SAPK/JNK, and ERK1/2 in Cultured Rat Cerebellar Astrocytes Exposed to Diphenylarsinic Acid [J].
Negishi, Takayuki ;
Matsumoto, Mami ;
Kobayashi, Yayoi ;
Kojima, Mikiya ;
Sakaguchi, Fumika ;
Takahata, Kazuaki ;
Kanehira, Tomoko ;
Arakaki, Rina ;
Aoyama, Yohei ;
Yoshida, Hikari ;
Yamada, Rena ;
Sumiyoshi, Nobutaka ;
Tashiro, Tomoko ;
Hirano, Seishiro ;
Yoshida, Kenji ;
Yukawa, Kazunori .
TOXICOLOGICAL SCIENCES, 2017, 156 (02) :509-519
[10]   Diphenylarsinic Acid Induced Activation of Cultured Rat Cerebellar Astrocytes: Phosphorylation of Mitogen-Activated Protein Kinases, Upregulation of Transcription Factors, and Release of Brain-Active Cytokines [J].
Negishi, Takayuki ;
Matsumoto, Mami ;
Kojima, Mikiya ;
Asai, Ryota ;
Kanehira, Tomoko ;
Sakaguchi, Fumika ;
Takahata, Kazuaki ;
Arakaki, Rina ;
Aoyama, Yohei ;
Yoshida, Hikari ;
Yoshida, Kenji ;
Yukawa, Kazunori ;
Tashiro, Tomoko ;
Hirano, Seishiro .
TOXICOLOGICAL SCIENCES, 2016, 150 (01) :74-83
12