Hepatic glucose sensing: does flux matter?

被引：3

作者：

Shiota, Masakazu ^{[2
]}

Magnuson, Mark A. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Sch Med, Ctr Stem Cell Biol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Physiol & Mol Biophys, Nashville, TN 37212 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2008年 / 118卷 / 03期

关键词：

D O I：

10.1172/JCI35137

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In this issue of the JCI, Denechaud et al. report studies investigating the role of the liver X receptors (LXRs) LXR alpha and LXR beta in carbohydrate sensing by the liver (see the related article beginning on page 956). The results of this study, which utilized LXR alpha/beta double-KO mice, strongly contradict a recent Nature report that proposed that LXR alpha/beta sense glucose independent of metabolic flux. The reported findings further support a key role for the carbohydrate-responsive element-binding protein (ChREBP) in the regulation of lipogenic genes by glucose and dietary carbohydrates.

引用

页码：841 / 844

页数：4

共 20 条

[1] CIS-REGULATION OF THE L-TYPE PYRUVATE-KINASE GENE PROMOTER BY GLUCOSE, INSULIN AND CYCLIC-AMP [J].

BERGOT, MO ;

DIAZGUERRA, MJM ;

PUZENAT, N ;

RAYMONDJEAN, M ;

KAHN, A .

NUCLEIC ACIDS RESEARCH, 1992, 20 (08) :1871-1878

[2] The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor [J].

Brown, MS ;

Goldstein, JL .

CELL, 1997, 89 (03) :331-340

[3] A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood [J].

Brown, MS ;

Goldstein, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11041-11048

[4] Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver [J].

Burgess, Shawn C. ;

Iizuka, Katsumi ;

Jeoung, Nam Ho ;

Harris, Robert A. ;

Kashiwaya, Yoshihiro ;

Veech, Richard L. ;

Kitazume, Tatsuya ;

Uyeda, Kosaku .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (03) :1670-1678

[5] The liver X receptor (LXR) and hepatic lipogenesis - The carbohydrate-response element-binding protein is a target gene of LXR [J].

Cha, Ji-Young ;

Repa, Joyce J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (01) :743-751

[6] ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver [J].

Denechaud, Pierre-Damien ;

Bossard, Pascale ;

Lobaccaro, Jean-Marc A. ;

Millatt, Lesley ;

Staels, Bart ;

Girard, Jean ;

Postic, Catherine .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (03) :956-964

[7]

Foretz M, 1999, MOL CELL BIOL, V19, P3760

[8] Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c [J].

Hegarty, BD ;

Bobard, A ;

Hainault, I ;

Ferré, P ;

Bossard, P ;

Foufelle, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (03) :791-796

[9] Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver [J].

Kabashima, T ;

Kawaguchi, T ;

Wadzinski, BE ;

Uyeda, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5107-5112

[10] Sweet dreams for LXR [J].

Lazar, Mitchell A. ;

Willson, Timothy M. .

CELL METABOLISM, 2007, 5 (03) :159-161

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