Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention

In 61 patients undergoing coronary intervention, the antithrombin activity of standard dose abciximab (n = 31) and weight-adjusted heparin was compared with the RE-STORE dose tirofiban (n = 30) and the same dose of weight-adjusted heparin. Serial measurements of the activated clotting time, prothrombin fragment F1.2, and GP IIb/IIIa receptor occupancy were obtained in a standardized protocol. There was no difference in antithrombin activity between these 2 compounds, suggesting that this activity represents a class effect related to inhibition of the GP IIb/IIa receptor alone.