Strength and durability of antibody responses to BNT162b2 and CoronaVac

被引：16
作者：
Cowling, Benjamin J. [1 ,2 ]
Wong, Irene O. L. [1 ]
Shiu, Eunice Y. C. [1 ]
Lai, Amber Y. T. [1 ]
Cheng, Samuel M. S. [1 ]
Chaothai, Sara [1 ]
Kwan, Kelvin K. H. [1 ]
Martin-Sanchez, Mario [1 ]
Poon, Leo L. M. [1 ,3 ,4 ]
Ip, Dennis K. M. [1 ]
Leung, Gabriel M. [1 ,2 ]
Leung, Nancy H. L. [1 ,2 ]
Peiris, J. S. Malik [1 ,3 ,4 ]
机构：
[1] Univ Hong Kong, LKS Fac Med, WHO Collaborating Ctr Infect Dis Epidemiol & Cont, Sch Publ Hlth, Hong Kong, Peoples R China
[2] Hong Kong Sci & Technol Pk, Lab Data Discovery Hlth, Hong Kong, Peoples R China
[3] Univ Hong Kong, Li Ka Shing Fac Med, HKU Pasteur Res Pole, Sch Publ Hlth, Hong Kong, Peoples R China
[4] Hong Kong Sci & Technol Pk, Ctr Immunol & Infect, Hong Kong, Peoples R China
来源：
VACCINE | 2022年 / 40卷 / 32期
基金：
美国国家卫生研究院; 英国惠康基金;
关键词：
COVID-19; Vaccination; Antibodies; MESSENGER-RNA;
D O I：
10.1016/j.vaccine.2022.05.033
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We studied 2780 adults in Hong Kong who received CoronaVac inactivated virus vaccine (Sinovac) and BNT162b2 mRNA vaccine ("Comirnaty", BioNTech/Fosun Pharma). We compared rates of antibody waning over time using an enzyme-linked immunosorbent assay for spike receptor binding domain and a surrogate virus neutralization test. We found stronger and more durable antibody responses to two doses of the mRNA vaccine, and slightly stronger initial antibody responses to each vaccine in younger adults and women. The weaker and less durable responses following CoronaVac support earlier provision of third doses to persons who previously received two doses of this vaccine. (C) 2022 The Author(s). Published by Elsevier Ltd.
引用
收藏
页码：4312 / 4317
页数：6
相关论文
共 19 条
  • [1] Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination
    Cheng, Samuel M. S.
    Mok, Chris Ka Pun
    Leung, Yonna W. Y.
    Ng, Susanna S.
    Chan, Karl C. K.
    Ko, Fanny W.
    Chen, Chunke
    Yiu, Karen
    Lam, Bosco H. S.
    Lau, Eric H. Y.
    Chan, Ken K. P.
    Luk, Leo L. H.
    Li, John K. C.
    Tsang, Leo C. H.
    Poon, Leo L. M.
    Hui, David S. C.
    Peiris, Malik
    [J]. NATURE MEDICINE, 2022, 28 (03) : 486 - +
  • [2] Evidence for antibody as a protective correlate for COVID-19 vaccines
    Earle, Kristen A.
    Ambrosino, Donna M.
    Fiore-Gartland, Andrew
    Goldblatt, David
    Gilbert, Peter B.
    Siber, George R.
    Dull, Peter
    Plotkin, Stanley A.
    [J]. VACCINE, 2021, 39 (32) : 4423 - 4428
  • [3] Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection
    Feng, Shuo
    Phillips, Daniel J.
    White, Thomas
    Sayal, Homesh
    Aley, Parvinder K.
    Bibi, Sagida
    Dold, Christina
    Fuskova, Michelle
    Gilbert, Sarah C.
    Hirsch, Ian
    Humphries, Holly E.
    Jepson, Brett
    Kelly, Elizabeth J.
    Plested, Emma
    Shoemaker, Kathryn
    Thomas, Kelly M.
    Vekemans, Johan
    Villafana, Tonya L.
    Lambe, Teresa
    Pollard, Andrew J.
    Voysey, Merryn
    [J]. NATURE MEDICINE, 2021, 27 (11) : 2032 - +
  • [4] Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant
    Gao, Yu
    Cai, Curtis
    Grifoni, Alba
    Muller, Thomas R.
    Niessl, Julia
    Olofsson, Anna
    Humbert, Marion
    Hansson, Lotta
    Osterborg, Anders
    Bergman, Peter
    Chen, Puran
    Olsson, Annika
    Sandberg, Johan K.
    Weiskopf, Daniela
    Price, David A.
    Ljunggren, Hans-Gustaf
    Karlsson, Annika C.
    Sette, Alessandro
    Aleman, Soo
    Buggert, Marcus
    [J]. NATURE MEDICINE, 2022, 28 (03) : 472 - +
  • [5] COVID-19 vaccine trials and sex-disaggregated data
    Hussain, Musaddique
    Fatima, Mehwish
    Muhammad Iqbal, Shahid
    Asif, Muhammad
    Saadullah, Malik
    Kashif-Ur-Rehman
    Mukhtar, Imran
    Ahmad Khan, Imran
    Parveen, Sajida
    Fayyaz, Tehreem
    Shabbir, Najia
    Kanwal, Aisha
    Shaukat, Saira
    Fatima, Mobeen
    Ikram, Nadia
    Majeed, Abdul
    Parveen, Farzana
    Tariq, Muhammad
    Barkat, Muhammad Qasim
    Zeng, Ling-Hui
    Wu, Ximei
    [J]. EXPERT REVIEW OF VACCINES, 2022, 21 (03) : 285 - 288
  • [6] Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
    Khoury, David S.
    Cromer, Deborah
    Reynaldi, Arnold
    Schlub, Timothy E.
    Wheatley, Adam K.
    Juno, Jennifer A.
    Subbarao, Kanta
    Kent, Stephen J.
    Triccas, James A.
    Davenport, Miles P.
    [J]. NATURE MEDICINE, 2021, 27 (07) : 1205 - +
  • [7] Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021
    Kwok, Shirley L. L.
    Cheng, Samuel M. S.
    Leung, Jennifer N. S.
    Leung, Kathy
    Lee, Cheuk-Kwong
    Peiris, J. S. Malik
    Wu, Joseph T.
    [J]. EUROSURVEILLANCE, 2022, 27 (02)
  • [8] Long-term persistence of SARS-CoV-2 neutralizing antibody responses after infection and estimates of the duration of protection
    Lau, Eric H. Y.
    Hui, David S. C.
    Tsang, Owen T. Y.
    Chan, Wai-Hung
    Kwan, Mike Y. W.
    Chiu, Susan S.
    Cheng, Samuel M. S.
    Ko, Ronald Lw
    Li, John K. C.
    Chaothai, Sara
    Tsang, Chi H.
    Poon, Leo L. M.
    Peiris, Malik
    [J]. ECLINICALMEDICINE, 2021, 41
  • [9] Comparative immunogenicity of mRNA and inactivated vaccines against COVID-19
    Lim, Wey Wen
    Mak, Loretta
    Leung, Gabriel M.
    Cowling, Benjamin J.
    Peiris, Malik
    [J]. LANCET MICROBE, 2021, 2 (09): : E423 - E423
  • [10] McMenamin ME, 2022, MEDRXIV, V2022, DOI [DOI 10.1101/2022.03.22.22272769, 10.1101/2022.03.22.22272769v2]
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