Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes

被引：132

作者：

Aggarwal, Trapti ^{[1
]}

Kumar, Sonu ^{[1
]}

Verma, Akhilesh K. ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Synthet Organ Chem Res Lab, Delhi 110007, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 32期

关键词：

ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; SUBSTITUTED QUINOLINES; BIOLOGICAL EVALUATION; RECEPTOR ANTAGONISTS; CASCADE CYCLIZATION; EFFICIENT SYNTHESIS; INDOLE ALKALOIDS; RECENT PROGRESS; DERIVATIVES;

D O I：

10.1039/c6ob01054g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iodine has been recognized as an efficient, non-toxic, readily available and easy-to-handle electrophilic reagent to favour halocyclization reactions for the synthesis of novel iodofunctionalized heterocyclic molecules that serve as versatile intermediates in synthetic organic chemistry. This review presents numerous useful methodologies for the synthesis of O, N, S, and Se-heterocycles through electrophilic cyclization via the attack of an electrophile on the C(sp) bond of alkynes. The cyclization proceeds under mild reaction conditions and tolerates a wide variety of functional groups.

引用

页码：7639 / 7653

页数：15

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