Consecutive Condensation, C-N and N-N Bond Formations: A Copper- Catalyzed One-Pot Three-Component Synthesis of 2H-Indazole

被引：183

作者：

Kumar, Manian Rajesh

Park, Ahbyeol

Park, Namjin

Lee, Sunwoo ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 13期

关键词：

COUPLING REACTIONS; ARYL AZIDES; CUPRIC ACETATE; DERIVATIVES; INDAZOLES; TAUTOMERISM; INHIBITORS; AMINATION; HALIDES; DESIGN;

D O I：

10.1021/ol201409j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2H-Indazoles are synthesized using copper-catalyzed, one-pot, three-component reactions of 2-bromobenzaldehydes, primary amines, and sodium azide. A copper catalyst plays the key role in the formation of C-N and N-N bonds. This method has a broad substrate scope with a high tolerance for a variety of functional groups.

引用

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页码：3542 / 3545

页数：4

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