Tuning the architectural integrity of high-performance magneto-fluorescent core-shell nanoassemblies in cancer cells

被引：15

作者：

Faucon, Adrien ^{[1
]}

Benhelli-Mokrani, Houda ^{[2
]}

Fleury, Fabrice ^{[2
]}

Dubreil, Laurence ^{[3
]}

Hulin, Philippe ^{[4
]}

Nedellec, Steven ^{[4
]}

Doussineau, Tristan ^{[5
]}

Antoine, Rodolphe ^{[5
]}

Orlando, Tomas ^{[6
]}

Lascialfari, Alessandro ^{[6
,7
,8
]}

Fresnais, Jerome

Lartigue, Lenaic ^{[1
,9
]}

Ishow, Elena ^{[1
]}

机构：

[1] Univ Nantes, CNRS, UMR 6230, CEISAM, 2 Rue Houssiniere, F-44322 Nantes, France

[2] Univ Nantes, CNRS, UMR 6204, UFIP, 2 Rue Houssiniere, F-44322 Nantes, France

[3] ONIRIS, Pan Ther UMR 703, INRA, F-44307 Nantes, France

[4] CNRS, UMS 3556, UMS 016, INSERM, 8 Quai Moncousu, F-44007 Nantes, France

[5] Univ Lyon, CNRS, UMR 5306, Inst Lumiere Mat, F-69622 Villeurbanne, France

[6] Univ Pavia, Dept Phys, Via Bassi, I-27100 Pavia, Italy

[7] Univ Milan, Dept Phys, Via Celoria 16, I-20133 Milan, Italy

[8] INSTM, Via Celoria 16, I-20133 Milan, Italy

[9] Univ Paris 06, Sorbonne Univ, CNRS, Lab PHENIX, 4 Pl Jussieu, F-75005 Paris, France

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2016年 / 479卷

关键词：

Fluorescent organic nanoparticles; Magnetism; Magneto-fluorescent nanoassemblies; Core-shell structure; Supraparticles; Bioimaging; INORGANIC NANOPARTICLES; BIOMEDICAL APPLICATIONS; ORGANIC NANOPARTICLES; MASS DETERMINATION; CONTRAST AGENTS; DRUG-DELIVERY; NANOHYBRIDS; WAVELENGTH; STABILITY; COMPLEXES;

D O I：

10.1016/j.jcis.2016.06.064

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

High-density nanoarchitectures, endowed with simultaneous fluorescence and contrast properties for MRI and TEM imaging, have been obtained using a simple self-assembling strategy based on supramolecular interactions between non-doped fluorescent organic nanoparticles (FON) and superparamagnetic nanoparticles. In this way, a high-payload core-shell structure FON@mag has been obtained, protecting the hydrophobic fluorophores from the surroundings as well as from emission quenching by the shell of magnetic nanoparticles. Compared to isolated nanoparticles, maghemite nanoparticles self-assembled as an external shell create large inhomogeneous magnetic field, which causes enhanced transverse relaxivity and exacerbated MRI contrast. The magnetic load of the resulting nanoassemblies is evaluated using magnetic sedimentation and more originally electrospray mass spectrometry. The role of the stabilizing agents (citrate versus polyacrylate anions) revealed to be crucial regarding the cohesion of the resulting high-performance magneto-fluorescent nanoassemblies, which questions their use after cell internalization as nanocarriers or imaging agents for reliable correlative light and electron microcopy. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：139 / 149

页数：11

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