Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates

被引：13

作者：

Bippus, Patrick ^{[1
]}

Skocic, Matthias ^{[2
]}

Jakupec, Michael A. ^{[2
]}

Keppler, Bernhard K. ^{[2
]}

Mohr, Fabian ^{[1
]}

机构：

[1] Berg Univ Wuppertal, Fachbereich Anorgan Chem C, D-42119 Wuppertal, Germany

[2] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2011年 / 105卷 / 03期

关键词：

Pt complexes; Cytotoxicity; cis geometry; X-ray structure; Thiocarbamate ligands; PLATINUM(II) COMPLEXES; STRUCTURE VALIDATION; LIGANDS; CRYSTAL; GOLD(I); 8-THIOTHEOPHYLLINE;

D O I：

10.1016/j.jinorgbio.2010.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The thiocarbamates 4-RC6H4NHC(S)NR2' (R = H, Cl; R' = Me, Et), 4-ClC6H4NHC(S)NR (NR = 2-pyridylpiperazine) react with cis-[PtCl2(PTA)(2)] (PTA = 1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the monocationic platinum(II) complexes cis-[Pt(SC(NR2')= NC6H4R)(PTA)(2)](+) (R = H, Cl; R' = Me, Et), cis-[Pt{SC (NR) = NC6H4Cl}(PTA)(2)](+) (NR = 2-pyridylpiperazine), which were isolated as their PF6 salts in high yields. The complexes were fully characterised spectroscopically and also by X-ray crystallography. Cytotoxicity of these complexes was studied in vitro in three human cancer cell lines (CH1, A549 and SW480) using the MTT assay. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：462 / 466

页数：5

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