The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses

被引：746

作者：

Trinchieri, G ^{[1
]}

Pflanz, S

Kastelein, RA

机构：

[1] Schering Plough Corp, Res Inst, Lab Immunol Res, F-69571 Dardilly, France

[2] DNAX Res Inst Mol & Cellular Biol Inc, Dept Discovery Biol, Palo Alto, CA 94304 USA

来源：

IMMUNITY | 2003年 / 19卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(03)00296-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Originally the only known heterodimeric cytokine, IL-12 is now part of a family of five cytokines and shares important functions in the regulation of both innate and adaptive immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were considered to have largely overlapping immunological functions, more recent studies, including two articles in this issue of Immunity (Hamano et al., 2003; Villarino et al., 2003), indicate that they mediate complex and well-differentiated functions.

引用

页码：641 / 644

页数：4

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