Significance of nuclear EGFR and ABCG2 expression in malignant transformation of oral potentially malignant disorders

被引：2
作者：
Tarle, Marko [1 ,2 ]
Muller, Danko [3 ,4 ]
Raguz, Marina [5 ,6 ]
Luksic, Ivica [1 ,4 ]
机构：
[1] Dubrava Univ Hosp, Dept Maxillofacial Surg, Gojko Susak Ave 6, Zagreb 10000, Croatia
[2] Univ Zagreb, Sch Dent Med, Zagreb, Croatia
[3] Dubrava Univ Hosp, Dept Pathol & Cytol, Zagreb, Croatia
[4] Univ Zagreb, Sch Med, Zagreb, Croatia
[5] Dubrava Univ Hosp, Dept Neurosurg, Zagreb, Croatia
[6] Catholic Univ Croatia, Sch Med, Zagreb, Croatia
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2022年 / 44卷 / 12期
关键词：
ABCG2; nuclear EGFR; oral cancer; oral erythroplakia; oral leukoplakia; EPIDERMAL-GROWTH-FACTOR; FACTOR RECEPTOR; SIDE-POPULATION; STEM-CELLS; CANCER; ERYTHROPLAKIA; LOCALIZATION; PODOPLANIN; HEAD; P53;
D O I：
10.1002/hed.27174
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background The purpose of this study was to investigate the expression of nuclear EGFR (nEGFR) and the stem cell marker ABCG2 in oral leukoplakia (OL) and oral erythroplakia (OE) and to assess their significance as prognostic biomarkers for malignant transformation. Methods In this study we included 50 patients with oral potentially malignant disorders (OPMD), 31 with OL and 19 with OE, in whom we examined the expression of nEGFR and ABCG2 by immunohistochemical methods. Results Twenty-one (42%) of 50 patients with OL and OE developed oral squamous cell carcinoma (OSCC). The malignant transformation was increased 12,84-fold (95% CI, 2.15-76.44, p = 0.005) in OPMD expressing both ABCG2 and nEGFR. Expression of nEGFR is a strong indicator of malignant transformation, unlike ABCG2 expression, respectively. Conclusions Determining the co-expression of the biomarkers nEGFR and ABCG2 in OPMD may serve us to determine the risk of malignant transformation in OSCC.
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收藏
页码：2668 / 2677
页数：10
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