Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition

被引：145

作者：

Solomon, E. A. ^{[1
]}

Kragel, J. E. ^{[2
]}

Sperling, M. R. ^{[3
]}

Sharan, A. ^{[4
]}

Worrell, G. ^{[5
]}

Kucewicz, M. ^{[5
]}

Inman, C. S. ^{[6
]}

Lega, B. ^{[7
]}

Davis, K. A. ^{[8
]}

Stein, J. M. ^{[9
]}

Jobst, B. C. ^{[10
]}

Zaghloul, K. A. ^{[11
]}

Sheth, S. A. ^{[12
]}

Rizzuto, D. S. ^{[2
]}

Kahana, M. J. ^{[2
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA

[3] Thomas Jefferson Univ Hosp, Dept Neurol, Philadelphia, PA 19107 USA

[4] Thomas Jefferson Univ Hosp, Dept Neurosurg, Philadelphia, PA 19107 USA

[5] Mayo Clin, Dept Physiol & Bioengn, Dept Neurol, Rochester, MN 55905 USA

[6] Emory Sch Med, Dept Neurosurg, Atlanta, GA 30322 USA

[7] Univ Texas Southwestern, Dept Neurosurg, Dallas, TX 75390 USA

[8] Hosp Univ Penn, Dept Neurol, 3400 Spruce St, Philadelphia, PA 19104 USA

[9] Hosp Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA

[10] Dartmouth Med Ctr, Dept Neurol, Lebanon, NH 03756 USA

[11] NIH, Surg Neurol Branch, Bethesda, MD 20814 USA

[12] Columbia Univ, Med Ctr, Dept Neurosurg, New York, NY 10032 USA

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

基金：

美国国家卫生研究院;

关键词：

OSCILLATION DETECTION METHOD; MEMORY FORMATION; PHASE SYNCHRONIZATION; VISUAL-CORTEX; HIPPOCAMPAL; INCREASES; COHERENCE; EXTRACTS; RHYTHMS; SPIKING;

D O I：

10.1038/s41467-017-01763-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The idea that synchronous neural activity underlies cognition has driven an extensive body of research in human and animal neuroscience. Yet, insufficient data on intracranial electrical connectivity has precluded a direct test of this hypothesis in a whole-brain setting. Through the lens of memory encoding and retrieval processes, we construct whole-brain connectivity maps of fast gamma (30-100 Hz) and slow theta (3-8 Hz) spectral neural activity, based on data from 294 neurosurgical patients fitted with indwelling electrodes. Here we report that gamma networks desynchronize and theta networks synchronize during encoding and retrieval. Furthermore, for nearly all brain regions we studied, gamma power rises as that region desynchronizes with gamma activity elsewhere in the brain, establishing gamma as a largely asynchronous phenomenon. The abundant phenomenon of theta synchrony is positively correlated with a brain region's gamma power, suggesting a predominant lowfrequency mechanism for inter-regional communication.

引用

页数：14

共 61 条

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