Epithelial to Mesenchymal Transition in Lung Cancer: Potential EMT-Targeting Natural Product-derived Compounds

被引:9
作者
Chanvorachote, Pithi [1 ,2 ]
Petsri, Korrakod [1 ,2 ]
Thongsom, Sunisa [1 ,2 ]
机构
[1] Chulalongkorn Univ, Fac Pharmaceut Sci, Ctr Excellence Canc Cell & Mol Biol, Bangkok, Thailand
[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacol & Physiol, Bangkok, Thailand
关键词
Epithelial to mesenchymal transition; lung cancer; potential compounds targeting EMT; review; NF-KAPPA-B; STEM-CELLS; TGF-BETA; INVASION; TRANSCRIPTION; MIGRATION; SNAIL; METASTASIS; PHENOTYPES; PATHWAY;
D O I
10.21873/anticanres.15923
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Epithelial to mesenchymal transition (EMT) is the cellular transition process of epithelium-associated phenotypes and behaviors into mesenchymal phenotypes. EMT is linked with cancer, and it is believed to be an important factor facilitating the motility and invasive activity of solid tumor cells. EMT facilitates the capability of cancer cells to metastasize because it promotes cell survival in detached conditions and facilitates the establishment of new tumors. In lung cancer, EMT has garnered considerable attention because of its importance in metastasis and has been recognized as an important target for anticancer drug therapy. Several studies have pointed out the promising activities of natural product-derived compounds and other agents that have EMT-suppressive activities and may facilitate the development of novel strategies for lung cancer management. In this review, we discuss the recent discoveries regarding the fundamental signaling regulating EMT and identify molecular targets for anti-EMT activities of the natural product-derived compounds. We also highlight the anti-EMT effect of natural compounds with their molecular targets and mechanisms of action that may benefit the understanding of and support the development of EMT targeting therapy.
引用
收藏
页码:4237 / 4246
页数:10
相关论文
共 82 条
[1]  
Ahlstrom JD, 2019, PRINCIPLES REGENERAT, P1
[2]   Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells [J].
Angela Nieto, M. .
SCIENCE, 2013, 342 (6159) :708-+
[3]   Natural products in drug discovery: advances and opportunities [J].
Atanasov, Atanas G. ;
Zotchev, Sergey B. ;
Dirsch, Verena M. ;
Supuran, Claudiu T. .
NATURE REVIEWS DRUG DISCOVERY, 2021, 20 (03) :200-216
[4]   Cancer stem cells as key drivers of tumour progression [J].
Ayob, Ain Zubaidah ;
Ramasamy, Thamil Selvee .
JOURNAL OF BIOMEDICAL SCIENCE, 2018, 25
[5]   Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration [J].
Bakin, AV ;
Tomlinson, AK ;
Bhowmick, NA ;
Moses, HL ;
Arteaga, CL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) :36803-36810
[6]   Snail1: A Transcriptional Factor Controlled at Multiple Levels [J].
Baulida, Josep ;
Diaz, Victor M. ;
Garcia de Herreros, Antonio .
JOURNAL OF CLINICAL MEDICINE, 2019, 8 (06)
[7]   The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression [J].
Cano, A ;
Pérez-Moreno, MA ;
Rodrigo, I ;
Locascio, A ;
Blanco, MJ ;
del Barrio, MG ;
Portillo, F ;
Nieto, MA .
NATURE CELL BIOLOGY, 2000, 2 (02) :76-83
[8]   Transcriptional repression of TWIST1 gene by Prospero-related homeobox 1 inhibits invasiveness of hepatocellular carcinoma cells [J].
Chang, Tsung-Ming ;
Hung, Wen-Chun .
FEBS LETTERS, 2012, 586 (20) :3746-3752
[9]   Iron induces cancer stem cells and aggressive phenotypes in human lung cancer cells [J].
Chanvorachote, Pithi ;
Luanpitpong, Sudjit .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2016, 310 (09) :C728-C739
[10]  
Chen Jia, 2021, J Oncol, V2021, P4391581, DOI 10.1155/2021/4391581