Kv4 (A-type) potassium currents in the mouse medial nucleus of the trapezoid body

被引：19

作者：

Johnston, Jamie ^{[1
,2
]}

Griffin, Sarah J. ^{[1
]}

Baker, Claire ^{[1
]}

Forsythe, Ian D. ^{[1
]}

机构：

[1] Univ Leicester, MRC Toxicol Unit, Leicester LE1 9HN, Leics, England

[2] Univ Leicester, Dept Cell Physiol & Pharmacol, Leicester LE1 9HN, Leics, England

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2008年 / 27卷 / 06期

基金：

英国医学研究理事会;

关键词：

auditory processing; current clamp; Hodgkin-Huxley model; K+ channel; voltage clamp;

D O I：

10.1111/j.1460-9568.2008.06116.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Principal neurones of the mouse medial nucleus of the trapezoid body (MNTB) possess multiple voltage-gated potassium currents, including a transient outward current (or A-current), which is characterized here. The A-current exhibited rapid voltage-dependent inactivation and was half inactivated at resting membrane potentials. Following a hyperpolarizing pre-pulse to remove inactivation, the peak transient current was 1.07 nA at -17 mV. The pharmacological characteristics of this A-current were consistent with Kv4 subunits in expression studies; the A-current was resistant to block by tetraethylammonium and dendrotoxin-I but sensitive to millimolar concentrations of 4-aminopyridine and 5 mu M hanatoxin. Immunohistochemistry confirmed that Kv4.3 sub-units are present in the MNTB. In a single-compartment model of an MNTB neurone, the A-current served to accelerate the decay of the initial action potentials in a stimulus train and suggested that removal of A-current steady-state inactivation could raise firing threshold for non-calyceal synaptic inputs. This A-type current was not observed in the rat.

引用

页码：1391 / 1399

页数：9

共 51 条

[1] Contribution of Kv4 channels toward the A-type potassium current in murine colonic myocytes [J].