Children primed and ready for SARS-CoV-2

被引：3
作者：
Speranza, Emily [1 ]
机构：
[1] NIAID, Lymphocyte Biol Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
来源：
NATURE MICROBIOLOGY | 2021年 / 6卷 / 11期
关键词：
D O I：
10.1038/s41564-021-00984-y
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Single-cell sequencing of nasal swab samples from people uninfected or infected with SARS-CoV-2 shows that children have a primed innate immune response, which may protect them from severe disease.
引用
收藏
页码：1337 / 1338
页数：2
相关论文
共 8 条
  • [1] Autoantibodies against type I IFNs in patients with life-threatening COVID-19
    Bastard, Paul
    Rosen, Lindsey B.
    Zhang, Qian
    Michailidis, Eleftherios
    Hoffmann, Hans-Heinrich
    Zhang, Yu
    Dorgham, Karim
    Philippot, Quentin
    Rosain, Jeremie
    Beziat, Vivien
    Manry, Jeremy
    Shaw, Elana
    Haljasmagi, Liis
    Peterson, Part
    Lorenzo, Lazaro
    Bizien, Lucy
    Trouillet-Assant, Sophie
    Dobbs, Kerry
    de Jesus, Adriana Almeida
    Belot, Alexandre
    Kallaste, Anne
    Catherinot, Emilie
    Tandjaoui-Lambiotte, Yacine
    Le Pen, Jeremie
    Kerner, Gaspard
    Bigio, Benedetta
    Seeleuthner, Yoann
    Yang, Rui
    Bolze, Alexandre
    Spaan, Andras N.
    Delmonte, Ottavia M.
    Abers, Michael S.
    Aiuti, Alessandro
    Casari, Giorgio
    Lampasona, Vito
    Piemonti, Lorenzo
    Ciceri, Fabio
    Bilguvar, Kaya
    Lifton, Richard P.
    Vasse, Marc
    Smadja, David M.
    Migaud, Melanie
    Hadjadj, Jerome
    Terrier, Benjamin
    Duffy, Darragh
    Quintana-Murci, Lluis
    van de Beek, Diederik
    Roussel, Lucie
    Vinh, Donald C.
    Tangye, Stuart G.
    [J]. SCIENCE, 2020, 370 (6515) : 423 - +
  • [2] Roles of Type I and III Interferons in COVID-19
    Choi, Hojun
    Shin, Eui-Cheol
    [J]. YONSEI MEDICAL JOURNAL, 2021, 62 (05) : 381 - 390
  • [3] COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis
    Chua, Robert Lorenz
    Lukassen, Soeren
    Trump, Saskia
    Hennig, Bianca P.
    Wendisch, Daniel
    Pott, Fabian
    Debnath, Olivia
    Thuermann, Loreen
    Kurth, Florian
    Voelker, Maria Theresa
    Kazmierski, Julia
    Timmermann, Bernd
    Twardziok, Sven
    Schneider, Stefan
    Machleidt, Felix
    Mueller-Redetzky, Holger
    Maier, Melanie
    Krannich, Alexander
    Schmidt, Sein
    Balzer, Felix
    Liebig, Johannes
    Loske, Jennifer
    Suttorp, Norbert
    Eils, Juergen
    Ishaque, Naveed
    Liebert, Uwe Gerd
    von Kalle, Christof
    Hocke, Andreas
    Witzenrath, Martin
    Goffinet, Christine
    Drosten, Christian
    Laudi, Sven
    Lehmann, Irina
    Conrad, Christian
    Sander, Leif-Erik
    Eils, Roland
    [J]. NATURE BIOTECHNOLOGY, 2020, 38 (08) : 970 - +
  • [4] Activation and evasion of type I interferon responses by SARS-CoV-2
    Lei, Xiaobo
    Dong, Xiaojing
    Ma, Ruiyi
    Wang, Wenjing
    Xiao, Xia
    Tian, Zhongqin
    Wang, Conghui
    Wang, Ying
    Li, Li
    Ren, Lili
    Guo, Fei
    Zhao, Zhendong
    Zhou, Zhuo
    Xiang, Zichun
    Wang, Jianwei
    [J]. NATURE COMMUNICATIONS, 2020, 11 (01)
  • [5] Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
    Liao, Mingfeng
    Liu, Yang
    Yuan, Jing
    Wen, Yanling
    Xu, Gang
    Zhao, Juanjuan
    Cheng, Lin
    Li, Jinxiu
    Wang, Xin
    Wang, Fuxiang
    Liu, Lei
    Amit, Ido
    Zhang, Shuye
    Zhang, Zheng
    [J]. NATURE MEDICINE, 2020, 26 (06) : 842 - +
  • [6] Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children
    Loske, J.
    Roehmel, J.
    Lukassen, S.
    Stricker, S.
    Magalhaes, Vg
    Liebig, J.
    Chua, Rl
    Thurmann, L.
    Messingschlager, M.
    Seegebarth, A.
    Timmermann, B.
    Klages, S.
    Ralser, M.
    Sawitzki, B.
    Sander, Le
    Corman, Vm
    Conrad, C.
    Laudi, S.
    Binder, M.
    Trump, S.
    Eils, R.
    Mall, M. A.
    Lehmann, I
    [J]. NATURE BIOTECHNOLOGY, 2022, 40 (03) : 319 - +
  • [7] Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
    Muus, Christoph
    Luecken, Malte D.
    Eraslan, Gokcen
    Sikkema, Lisa
    Waghray, Avinash
    Heimberg, Graham
    Kobayashi, Yoshihiko
    Vaishnav, Eeshit Dhaval
    Subramanian, Ayshwarya
    Smillie, Christopher
    Jagadeesh, Karthik A.
    Duong, Elizabeth Thu
    Fiskin, Evgenij
    Triglia, Elena Torlai
    Ansari, Meshal
    Cai, Peiwen
    Lin, Brian
    Buchanan, Justin
    Chen, Sijia
    Shu, Jian
    Haber, Adam L.
    Chung, Hattie
    Montoro, Daniel T.
    Adams, Taylor
    Aliee, Hananeh
    Allon, Samuel J.
    Andrusivova, Zaneta
    Angelidis, Ilias
    Ashenberg, Orr
    Bassler, Kevin
    Becavin, Christophe
    Benhar, Inbal
    Bergenstrahle, Joseph
    Bergenstrahle, Ludvig
    Bolt, Liam
    Braun, Emelie
    Bui, Linh T.
    Callori, Steven
    Chaffin, Mark
    Chichelnitskiy, Evgeny
    Chiou, Joshua
    Conlon, Thomas M.
    Cuoco, Michael S.
    Cuomo, Anna S. E.
    Deprez, Marie
    Duclos, Grant
    Fine, Denise
    Fischer, David S.
    Ghazanfar, Shila
    Gillich, Astrid
    [J]. NATURE MEDICINE, 2021, 27 (03) : 546 - +
  • [8] Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19
    Trump, Saskia
    Lukassen, Soeren
    Anker, Markus S.
    Chua, Robert Lorenz
    Liebig, Johannes
    Thurmann, Loreen
    Corman, Victor Max
    Binder, Marco
    Loske, Jennifer
    Klasa, Christina
    Krieger, Teresa
    Hennig, Bianca P.
    Messingschlager, Marey
    Pott, Fabian
    Kazmierski, Julia
    Twardziok, Sven
    Albrecht, Jan Philipp
    Eils, Jurgen
    Hadzibegovic, Sara
    Lena, Alessia
    Heidecker, Bettina
    Burgel, Thore
    Steinfeldt, Jakob
    Goffinet, Christine
    Kurth, Florian
    Witzenrath, Martin
    Volker, Maria Theresa
    Muller, Sarah Dorothea
    Liebert, Uwe Gerd
    Ishaque, Naveed
    Kaderali, Lars
    Sander, Leif-Erik
    Drosten, Christian
    Laudi, Sven
    Eils, Roland
    Conrad, Christian
    Landmesser, Ulf
    Lehmann, Irina
    [J]. NATURE BIOTECHNOLOGY, 2021, 39 (06) : 705 - 716
1