Regulation of Wnt gene expression

被引:2
作者
Tian, Q
Jin, H
Cui, YZ
Guo, CS
Lu, X
机构
[1] Oregon Hlth & Sci Univ, Sch Med, Dept Pathol, Portland, OR 97239 USA
[2] Oregon Coll Oriental Med, Portland, OR 97216 USA
[3] Oregon Hlth & Sci Univ, OGI Sch Sci & Engn, Dept Environm & Biochem Sci, Beaverton, OR 97006 USA
[4] Shriners Hosp Children, Portland Unit, Portland, OR 97201 USA
[5] Nanjing Med Univ, Jiangsu Prov Hosp, Dept Cardiol, Nanjing 210029, Peoples R China
关键词
gene expression; post-transcription; transcription; translation; Wnt;
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Members of the Wnt gene family play important roles in the regulation of a number of basic developmental processes. Because Wnt is such a potent morphogen, its expression must be controlled tightly and precisely. While many review papers focused on Wnt signaling downstream of the receptor, this review addresses regulations of Wnt itself on several levels, including the transcriptional level, RNA splicing, the post-transcriptional level, the translational level, and the post-translational level. It is these multiple, precise and tight regulations that guarantee that Wnts function correctly both temporally and spatially.
引用
收藏
页码:273 / 281
页数:9
相关论文
共 95 条
  • [41] Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development
    Lagutin, OV
    Zhu, CQC
    Kobayashi, D
    Topczewski, J
    Shimamura, K
    Puelles, L
    Russell, HRC
    McKinnon, PJ
    Solnica-Krezel, L
    Oliver, G
    [J]. GENES & DEVELOPMENT, 2003, 17 (03) : 368 - 379
  • [42] Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning
    Lekven, AC
    Thorpe, CJ
    Waxman, JS
    Moon, RT
    [J]. DEVELOPMENTAL CELL, 2001, 1 (01) : 103 - 114
  • [43] Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia
    Ligon, KL
    Echelard, Y
    Assimacopoulos, S
    Danielian, PS
    Kaing, S
    Grove, EA
    McMahon, AP
    Rowitch, DH
    [J]. DEVELOPMENT, 2003, 130 (10): : 2275 - 2287
  • [44] Zebrafish wnt4b expression in the floor plate is altered in sonic hedgehog and gli-2 mutants
    Liu, AP
    Majumdar, A
    Schauerte, HE
    Haffter, P
    Drummond, IA
    [J]. MECHANISMS OF DEVELOPMENT, 2000, 91 (1-2) : 409 - 413
  • [45] The Wnt signaling pathway in development and disease
    Logan, CY
    Nusse, R
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2004, 20 : 781 - 810
  • [46] The lack of Emx2 causes impairment of Reelin signaling and defects of neuronal migration in the developing cerebral cortex
    Mallamaci, A
    Mercurio, S
    Muzio, L
    Cecchi, C
    Pardini, CL
    Gruss, P
    Boncinelli, E
    [J]. JOURNAL OF NEUROSCIENCE, 2000, 20 (03) : 1109 - 1118
  • [47] Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation
    Mariottini, P
    Shah, ZH
    Toivonen, JM
    Bagni, C
    Spelbrink, JN
    Amaldi, F
    Jacobs, HT
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) : 31853 - 31862
  • [48] MUTATIONAL ANALYSIS OF MOUSE WNT-1 IDENTIFIES 2 TEMPERATURE-SENSITIVE ALLELES AND ATTRIBUTES OF WNT-1 PROTEIN ESSENTIAL FOR TRANSFORMATION OF A MAMMARY CELL-LINE
    MASON, JO
    KITAJEWSKI, J
    VARMUS, HE
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (05) : 521 - 533
  • [49] THE WNT FAMILY OF DEVELOPMENTAL REGULATORS
    MCMAHON, AP
    [J]. TRENDS IN GENETICS, 1992, 8 (07) : 236 - 242
  • [50] THE WNT-1 (INT-1) PROTOONCOGENE IS REQUIRED FOR DEVELOPMENT OF A LARGE REGION OF THE MOUSE-BRAIN
    MCMAHON, AP
    BRADLEY, A
    [J]. CELL, 1990, 62 (06) : 1073 - 1085