Response to Air Insufflation in Patients with Non-erosive Gastro-oesophageal Reflux Disease (NERD)

被引：0
|
作者：
Kira, F. [1 ]
Suzuki, T. [1 ]
Suyama, Y. [1 ]
Nishimura, S. [1 ]
Ogura, K. [1 ]
机构：
[1] Tokyo Metropolitan Police Hosp, Div Gastroenterol, Nakano Ku, Tokyo 1640001, Japan
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2011年 / 39卷 / 01期
关键词：
RABEPRAZOLE; NERD; NON-EROSIVE GASTRO-OESOPHAGEAL REFLUX DISEASE; GASTRIC SENSITIVITY; ENDOSCOPY; AIR INSUFFLATION; SENSORIMOTOR FUNCTION; RABEPRAZOLE; OMEPRAZOLE; DISTENSION; DYSPEPSIA; SYMPTOMS; HUMANS; TRIAL; TONE;
D O I：
10.1177/147323001103900123
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
This study compared changes in intragastric pressure (IGP) in response to a gastric distension stimulus caused by air insufflation in 25 patients with non-erosive gastro-oesophageal reflux disease (NERD) and 34 healthy volunteers (controls). In four NERD patients, IGP responses were also measured before and after oral treatment with 10 mg rabeprazole daily for 2 weeks. The rate of increase in IGP at the start of insufflation was significantly higher in NERD patients than in controls. The time to appearance of symptoms (i.e. time to threshold) was significantly shorter in NERD patients than in controls. Direct measurement of IGP showed that visceral hypersensitivity and impaired fundal relaxation are both characteristic of NERD. Administration of rabeprazole led to a marked prolonging of time to threshold, indicating that treatment could alleviate this hypersensitivity.
引用
收藏
页码：215 / 221
页数：7
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