A molecular basis for damage recognition in eukaryotic nucleotide excision repair

被引：12

作者：

Schaerer, Orlando D. ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Pharmacol Sci, Stony Brook, NY 11974 USA

来源：

CHEMBIOCHEM | 2008年 / 9卷 / 01期

关键词：

DNA damage; DNA repair; molecular recognition; xeroderma pigmentosum; X-ray crystallography;

D O I：

10.1002/cbic.200700619

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Figure Presented) How to spot a lesion. A recent report from Min and Pavletich provides a molecular basis for how a variety of structurally diverse lesions are recognized in eukaryotic nucleotide excision repair. The initial damage sensor XPC/HR23B probes the DNA helix for thermodynamically destabilized sites and interacts with undamaged nucleotides opposite a DNA lesion. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：21 / 23

页数：3

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