Tandem radical cyclization of N-methacryloyl benzamides with CBr4 to construct brominated isoquinolinediones

被引：20

作者：

Huang, Songhai ^{[1
]}

Niu, Pengfei ^{[1
]}

Su, Yingpeng ^{[1
]}

Hu, Dongcheng ^{[1
]}

Huo, Congde ^{[1
]}

机构：

[1] Northeast Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Ecoenvironm Related Polymer Mat, Lanzhou 730070, Gansu, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 41期

基金：

中国国家自然科学基金;

关键词：

METAL-FREE; ACTIVATED ALKENES; ORGANOHALOGEN COMPOUNDS; CUMENE HYDROPEROXIDE; SELECTIVE INHIBITORS; CARBON TETRABROMIDE; DERIVATIVES; CATALYST; ISOQUINOLINE-1,3(2H,4H)-DIONES; ADDITION/CYCLIZATION;

D O I：

10.1039/c8ob01964a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple cumene (isopropylbenzene, IPB) promoted auto-oxidation involved tandem radical cyclization of N-methacryloyl benzamides using stable and easy-to-handle CBr4 as the bromine source is described. This strategy provides an efficient and practical approach for the synthesis of bromine containing isoquinolinediones. This method also presents a new way to generate bromine radicals using a mild auto-oxidation pathway.

引用

页码：7748 / 7752

页数：5

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