Insulin-like growth factor I potentiates kainate receptors through a phosphatidylinositol 3-kinase dependent pathway

被引：28

作者：

de la Vega, AG ^{[1
]}

Buño, W ^{[1
]}

Pons, S ^{[1
]}

Garcia-Calderat, MS ^{[1
]}

Garcia-Galloway, E ^{[1
]}

Torres-Aleman, I ^{[1
]}

机构：

[1] CSIC, Inst Cajal, E-28002 Madrid, Spain

来源：

NEUROREPORT | 2001年 / 12卷 / 06期

关键词：

insulin-like growth factor I; ionotropic glutamate receptors; kainate receptors; phosphatidylinositol; 3-kinase; synaptic plasticity;

D O I：

10.1097/00001756-200105080-00047

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurotrophic factors modulate synaptic plasticity through mechanisms that include regulation of membrane ion channels and neurotransmitter receptors. Recently, it was shown that insulin-like growth factor I (IGF-I) induces depression of AMPA-mediated currents without affecting NMDA-receptor function in neurons. We now report that IGF-I markedly potentiates the kainate-preferring ionotropic glutamate receptor in young cerebellar granule neurons expressing functional kainate-, but not AMPA-mediated currents. Potentiation of kainate responses by IGF-I is blocked by wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor, indicating a role for this kinase in the effect of IGF-I. These results reinforce the notion that modulation of ionotropic glutamate receptors are involved in the regulatory actions of IGF-I on neuronal plasticity. NeuroReport 12:1293-1296 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：1293 / 1296

页数：4

共 18 条

[1] Insulin-like growth factor-I and central nervous system development [J].