Polypharmacy Is Significantly and Positively Associated with the Frailty Status Assessed Using the 5-Item FRAIL Scale, Cardiovascular Health Phenotypic Classification of Frailty Index, and Study of Osteoporotic Fractures Scale

被引：5

作者：

Hung, Chi-Di ^{[1
,2
,3
,4
]}

Yang, Chen-Cheng ^{[1
,2
,3
,4
]}

Lee, Chun-Ying ^{[4
]}

Hu, Stephen Chu-Sung ^{[5
]}

Chen, Szu-Chia ^{[6
]}

Hung, Chih-Hsing ^{[7
]}

Chuang, Hung-Yi ^{[2
]}

Chen, Ching-Yu ^{[8
]}

Kuo, Chao-Hung ^{[6
]}

机构：

[1] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Occupat & Environm Med, Kaohsiung 812, Taiwan

[2] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Occupat & Environm Med, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Family Med, Kaohsiung 812, Taiwan

[4] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 807, Taiwan

[5] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Dermatol, Kaohsiung 812, Taiwan

[6] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan

[7] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Environm & Occupat Med Ctr, Kaohsiung 812, Taiwan

[8] Natl Taiwan Univ Hosp, Dept Family Med, Taipei 100, Taiwan

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 19期

关键词：

polypharmacy; frailty; Cardiovascular Health Study; Study of Osteoporotic Fracture; OLDER-PEOPLE; POPULATION; ADULTS; AGE; PREVALENCE; MANAGEMENT; DISABILITY; LEVEL; RISK;

D O I：

10.3390/jcm10194413

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to investigate the association between frailty and polypharmacy using three different frailty screening tools. This was a cross-sectional study of people aged >= 65 years. Participants were included and interviewed using questionnaires. Polypharmacy was defined as the daily use of eight or more pills. Frailty was assessed using a screening tool, including (1) the Fatigue, Resistance, Ambulation, Illness and Loss of Weight Index (5-item FRAIL scale), (2) the Cardiovascular Health Phenotypic Classification of Frailty (CHS_PCF) index (Fried's Frailty Phenotype), and (3) the Study of Osteoporotic Fracture (SOF) scale. A total of 205 participants (mean age: 71.1 years; 53.7% female) fulfilled our inclusion criteria. The proportion of patients with polypharmacy was 14.1%. After adjustments were made for comorbidity or potential confounders, polypharmacy was associated with frailty on the 5-item FRAIL scale (adjusted odds ratio [aOR]: 9.12; 95% confidence interval [CI]: 3.6-23.16), CHS_PCF index (aOR: 8.98; 95% CI: 2.51-32.11), and SOF scale (aOR: 6.10; 95% CI: 1.47-25.3). Polypharmacy was associated with frailty using three frailty screening tools. Future research is required to further enhance our understanding of the risk of frailty among older adults.

引用

页数：10

共 1 条

[1] Physical frailty identification using machine learning to explore the 5-item FRAIL scale, Cardiovascular Health Study index, and Study of Osteoporotic Fractures index
Yang, Chen-Cheng
Chen, Po-Hong
Yang, Cheng-Hong
Dai, Chia-Yen
Luo, Kuei-Hau
Chen, Tzu-Hua
Chuang, Hung-Yi
Kuo, Chao-Hung
FRONTIERS IN PUBLIC HEALTH, 2024, 12

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