Role of acoustic radiation force impulse imaging elastography in the assessment of steatohepatitis and fibrosis in rat models

被引：3

作者：

Guo, Yanrong ^{[1
]}

Lin, Haoming ^{[1
]}

Dong, Changfeng ^{[2
]}

Zhang, Xinyu ^{[1
]}

Wen, Huiying ^{[1
]}

Shen, Yuanyuan ^{[1
]}

Wang, Tianfu ^{[1
]}

Chen, Siping ^{[1
]}

Liu, Yingxia ^{[2
]}

Chen, Xin ^{[1
]}

机构：

[1] Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasoun, Natl Reg Key Technol Engn Lab Med Ultrasound, Shenzhen, Peoples R China

[2] Third Peoples Hosp Shenzhen, Shenzhen Inst Hepatol, Shenzhen, Peoples R China

来源：

MEDICAL ENGINEERING & PHYSICS | 2018年 / 59卷

基金：

中国国家自然科学基金;

关键词：

Acoustic radiation force impulse; Elastography; Fibrosis; Steatosis; Inflammation; NONALCOHOLIC FATTY LIVER; MAGNETIC-RESONANCE ELASTOGRAPHY; TRANSIENT ELASTOGRAPHY; STIFFNESS MEASUREMENT; CLINICAL-USE; EX-VIVO; NONINVASIVE ASSESSMENT; HEPATIC-FIBROSIS; WFUMB GUIDELINES; DISEASE;

D O I：

10.1016/j.medengphy.2018.06.003

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Acoustic radiation force impulse (ARFI) elastography is a non-invasive method for performing liver assessment via liver shear wave velocity (SWV) measurements. The aim of this study was to evaluate the performance of the ARFI technique in the diagnosis of nonalcoholic steatohepatitis (NASH) and fibrosis and to investigate the effect of steatosis and inflammation on liver fibrosis SWV measurements in a rat model of nonalcoholic fatty liver disease (NAFLD). The ex vivo right liver lobes from 110 rats were processed and embedded in a fabricated gelatin phantom, and the other lobes were used for histologic assessment. The SWV induced by acoustic radiation force was derived to evaluate liver stiffness. The experimental results showed that the liver SWV value could be used to differentiate non-NASH rats from NASH-presenting rats and NASH from cirrhosis, and these comparisons showed areas under the receiver operating characteristic curves (AUROC) of 0.951 and 0.980, respectively. The diagnostic performances of ARFI elastography in predicting severe fibrosis (F >= 3) and cirrhosis (F >= 4) showed AUROC values of 0.997 and 0.993, respectively. In rats with mild fibrosis (F0-F1), severe steatosis had a significant effect on the mean SWV values. In rats with significant fibrosis (F2-F4), severe lobular inflammation had significant effects on the mean SWV values. Our findings indicate that ARFI elastography is a promising method for differentiating non-NASH rats from NASH rats and for staging hepatic fibrosis in NASH. The presence of severe steatosis and severe lobular inflammation are significant factors for evaluating fibrosis stages. (C) 2018 IPEM. Published by Elsevier Ltd. All rights reserved.

引用

页码：30 / 35

页数：6

共 43 条

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