Novozym-435 as efficient catalyst for the synthesis of benzoic and (hetero)aromatic carboxylic acid esters

被引：5

作者：

Giunta, Daniela ^{[1
]}

Sechi, Barbara ^{[1
]}

Solinas, Maurizio ^{[1
]}

机构：

[1] Ist Chim Biomol CNR UOS SS, I-07100 Sassari, Italy

来源：

TETRAHEDRON | 2015年 / 71卷 / 18期

关键词：

Novozym-435; Lipase; Esterification; Benzoic acids; CANDIDA-ANTARCTICA LIPASE; ENZYMATIC-SYNTHESIS; ESTERIFICATION; CONFORMATION; PRETREATMENT;

D O I：

10.1016/j.tet.2015.03.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hereby we report new reaction conditions to convert benzoic acids and more general (hetero)aromatic carboxylic acids into the corresponding n-heptyl esters by applying Novozym-435 as the biocatalyst in cyclohexane as the solvent. Very good yields are obtained in the esterification of a plethora of substituted acids with mild and straightforward reaction conditions. Direct esterification of the acid is favoured compared to transesterification of methyl benzoate under our reaction conditions in all cases studied. Recycling of the immobilised enzyme is feasible although With some minor limitations. (C) 2015 Published by Elsevier Ltd.

引用

页码：2692 / 2697

页数：6

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