Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application

被引：8

作者：

Sinai, Adam ^{[1
,2
]}

Simko, Daniel Cs. ^{[2
]}

Szabo, Fruzsina ^{[2
]}

Paczal, Attila ^{[1
]}

Gati, Tamas ^{[1
]}

Benyei, Attila ^{[3
]}

Novak, Zoltan ^{[2
]}

Kotschy, Andras ^{[1
]}

机构：

[1] Servier Res Inst Med Chem, Zahony Utca 7, H-1031 Budapest, Hungary

[2] Eotvos Lorand Univ, Inst Chem, ELTE Lendulet Catalysis & Organ Synth Res Grp, Pazmany Peter Stny 1-A, H-1117 Budapest, Hungary

[3] Univ Debrecen, Dept Pharmaceut Chem, Egyet Ter 1, H-4032 Debrecen, Hungary

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 09期

关键词：

Amination; Cross-coupling; Homogeneous catalysis; Palladium; Phosphine ligands; SUZUKI-MIYAURA; N-TOSYLHYDRAZONES; ROOM-TEMPERATURE; HOMOGENEOUS CATALYSTS; CHLORIDES; SONOGASHIRA; AMINATION; HALIDES; LIBRARIES; ARYLATION;

D O I：

10.1002/ejoc.201901834

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis, temperature-dependent NMR structure investigation and utilization of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In our study, we demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

引用

页码：1122 / 1128

页数：7

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