Advances in the Regulation of Macrophage Polarization by Mesenchymal Stem Cells and Implications for ALI/ARDS Treatment

被引:63
作者
Liu, Chang [1 ,2 ,3 ]
Xiao, Kun [2 ,3 ]
Xie, Lixin [2 ,3 ]
机构
[1] Nankai Univ, Sch Med, Tianjin, Peoples R China
[2] Chinese Peoples Liberat Army PLA Gen Hosp, Ctr Pulm & Crit Care Med, Beijing, Peoples R China
[3] Chinese Peoples Liberat Army PLA, Med Sch, Beijing, Peoples R China
基金
英国科研创新办公室;
关键词
macrophage polarization; mesenchymal stem cells; acute lung injury; acute respiratory distress syndrome; treatment; RESPIRATORY-DISTRESS-SYNDROME; ACUTE LUNG INJURY; EXTRACELLULAR VESICLES; STROMAL CELLS; MECHANICAL VENTILATION; MITOCHONDRIAL TRANSFER; IMMUNE MODULATION; OXIDATIVE STRESS; M2; POLARIZATION; KAPPA-B;
D O I
10.3389/fimmu.2022.928134
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common condition with high mortality. ALI/ARDS is caused by multiple etiologies, and the main clinical manifestations are progressive dyspnea and intractable hypoxemia. Currently, supportive therapy is the main ALI/ARDS treatment, and there remains a lack of targeted and effective therapeutic strategies. Macrophages are important components of innate immunity. M1 macrophages are pro-inflammatory, while M2 macrophages are anti-inflammatory and promote tissue repair. Mesenchymal stem cells (MSCs) are stem cells with broad application prospects in tissue regeneration due to their multi-directional differentiation potential along with their anti-inflammatory and paracrine properties. MSCs can regulate the balance of M1/M2 macrophage polarization to improve the prognosis of ALI/ARDS. In this paper, we review the mechanisms by which MSCs regulate macrophage polarization and the signaling pathways associated with polarization. This review is expected to provide new targets for the treatment of ALI/ARDS.
引用
收藏
页数:14
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共 171 条
[1]   Diverse macrophage populations mediate acute lung inflammation and resolution [J].
Aggarwal, Neil R. ;
King, Landon S. ;
D'Alessio, Franco R. .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2014, 306 (08) :L709-L725
[2]   Functional roles of STAT family proteins: Lessons from knockout mice [J].
Akira, S .
STEM CELLS, 1999, 17 (03) :138-146
[3]   Exosome-delivered microRNAs modulate the inflammatory response to endotoxin [J].
Alexander, Margaret ;
Hu, Ruozhen ;
Runtsch, Marah C. ;
Kagele, Dominique A. ;
Mosbruger, Timothy L. ;
Tolmachova, Tanya ;
Seabra, Miguel C. ;
Round, June L. ;
Ward, Diane M. ;
O'Connell, Ryan M. .
NATURE COMMUNICATIONS, 2015, 6
[4]   Nuclear factor-kappa B and its role in inflammatory lung disease [J].
Alharbi, Khalid Saad ;
Fuloria, Neeraj Kumar ;
Fuloria, Shivkanya ;
Rahman, Sk Batin ;
Al-Malki, Waleed Hassan ;
Shaikh, Mohammad Arshad Javed ;
Thangavelu, Lakshmi ;
Singh, Sachin K. ;
Allam, Venkata Sita Rama Raju ;
Jha, Niraj Kumar ;
Chellappan, Dinesh Kumar ;
Dua, Kamal ;
Gupta, Gaurav .
CHEMICO-BIOLOGICAL INTERACTIONS, 2021, 345
[5]   Alveolar Macrophages in the Resolution of Inflammation, Tissue Repair, and Tolerance to Infection [J].
Allard, Benoit ;
Panariti, Alice ;
Martin, James G. .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[6]   Mesenchymal Stem/Stromal Cells and Their Paracrine Activity-Immunomodulation Mechanisms and How to Influence the Therapeutic Potential [J].
Alvites, Rui ;
Branquinho, Mariana ;
Sousa, Ana C. ;
Lopes, Bruna ;
Sousa, Patricia ;
Mauricio, Ana Colette .
PHARMACEUTICS, 2022, 14 (02)
[7]   Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage phenotypes [J].
Anders, Catherine B. ;
Lawton, Tyler M. W. ;
Smith, Hannah L. ;
Garret, Jamie ;
Doucette, Margaret M. ;
Ammons, Mary Cloud B. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2022, 111 (03) :667-693
[8]   Notch signaling: Cell fate control and signal integration in development [J].
Artavanis-Tsakonas, S ;
Rand, MD ;
Lake, RJ .
SCIENCE, 1999, 284 (5415) :770-776
[9]   Extracellular Vesicles From Adipose Tissue-Derived Stem Cells Affect Notch-miR148a-3p Axis to Regulate Polarization of Macrophages and Alleviate Sepsis in Mice [J].
Bai, Xiaozhi ;
Li, Junjie ;
Li, Lincheng ;
Liu, Mingchuan ;
Liu, Yang ;
Cao, Mengyuan ;
Tao, Ke ;
Xie, Songtao ;
Hu, Dahai .
FRONTIERS IN IMMUNOLOGY, 2020, 11
[10]   MicroRNA-21 mediates bone marrow mesenchymal stem cells protection of radiation-induced lung injury during the acute phase by regulating polarization of alveolar macrophages [J].
Bao, Peugtao ;
Zhao, Weiguo ;
Mou, Mi ;
Liu, Xiaofei .
TRANSLATIONAL CANCER RESEARCH, 2020, 9 (01) :231-239