No Association Between the DAT1 10-Repeat Allele and ADHD in the Iranian Population

被引：13

作者：

Banoei, M. M. ^{[3
]}

Majidizadeh, T. ^{[3
]}

Shirazi, E. ^{[2
]}

Moghimi, N. ^{[1
]}

Ghadiri, M. ^{[1
]}

Najmabadi, H. ^{[1
]}

Ohadi, M. ^{[1
]}

机构：

[1] Univ Social Welf & Rehabil Sci, Genet Res Ctr, Tehran, Iran

[2] Iran Univ Med Sci, Mental Hlth Res Ctr, Tehran, Iran

[3] Natl Inst Genet Engn & Biotechnol, Tehran, Iran

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2008年 / 147B卷 / 01期

关键词：

ADHD; DAT1; VNTR; polymorphism; association;

D O I：

10.1002/ajmg.b.30578

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Association studies between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of a polymorphism (a 40 bp variable number of tandem repeats) in the dopamine transporter gene (DAT1) have resulted in mixed findings in different populations. We performed a case/control study to clarify the contribution of this allele with ADHD in the Iranian population. No association was observed between the 10-allele and disease (chi(2) = 0.081, P < 0.9). Furthermore, no significant difference was observed in the homozygosity of this allele between the case and control groups (chi(2) = 0.022, P < 0.9). Implication of the dopamine transporter gene in the pathophysiology of ADHD warrants investigation of other functional polymorphisms within this gene in the Iranian ADHD patients. (C) 2007 Wiley-Liss, Inc.

引用

页码：110 / 111

页数：2

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