Patient-specific neural progenitor cells derived from induced pluripotent stem cells offer a promise of good models for mitochondrial disease

被引：6

作者：

Liang, Xiao ^{[1
,2
]}

Kristiansen, Cecilie Katrin ^{[1
]}

Vatne, Guro Helen ^{[1
]}

Hong, Yu ^{[2
]}

Bindoff, Laurence Albert ^{[1
,2
]}

机构：

[1] Univ Bergen, Dept Clin Med, Mitochondrial Med & Neurogenet MMN Grp, POB 7804, N-5020 Bergen, Norway

[2] Haukeland Hosp, Dept Neurol, Bergen, Norway

来源：

CELL AND TISSUE RESEARCH | 2020年 / 380卷 / 01期

关键词：

Neural progenitor cells; Induced pluripotent stem cells; Mitochondrial disease; mtDNA; Disease modeling; AMYOTROPHIC-LATERAL-SCLEROSIS; DNA MUTATIONS; DRUG DISCOVERY; MERRF-SYNDROME; ALZHEIMERS-DISEASE; MYOCLONIC EPILEPSY; GENOMIC STABILITY; A8344G MUTATION; POINT MUTATION; TRANSPLANTATION;

D O I：

10.1007/s00441-019-03164-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondria are the primary generators of ATP in eukaryotic cells through the process of oxidative phosphorylation. Mitochondria are also involved in several other important cellular functions including regulation of intracellular Ca2+, cell signaling and apoptosis. Mitochondrial dysfunction causes disease and since it is not possible to perform repeated studies in humans, models are essential to enable us to investigate the mechanisms involved. Recently, the discovery of induced pluripotent stem cells (iPSCs), made by reprogramming adult somatic cells (Takahashi and Yamanaka 2006; Yamanaka and Blau 2010), has provided a unique opportunity for studying aspects of disease mechanisms in patient-specific cells and tissues. Reprogramming cells to neuronal lineage such as neural progenitor cells (NPCs) generated from the neural induction of reprogrammed iPSCs can thus provide a useful model for investigating neurological disease mechanisms including those caused by mitochondrial dysfunction. In addition, NPCs display a huge clinical potential in drug screening and therapeutics.

引用

页码：15 / 30

页数：16

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