The roles of Wnt/β-catenin signaling pathway related lncRNAs in cancer

被引：68
|
作者：
Hu, Xiao-Yi [1 ,2 ,4 ]
Hou, Ping-Fu [1 ,2 ]
Li, Teng-Teng [5 ]
Quan, Hao-Yu [1 ,2 ]
Li, Min-Le [1 ,2 ]
Lin, Tian [1 ,2 ]
Liu, Jin-Jin [1 ,2 ]
Bai, Jin [1 ,2 ]
Zheng, Jun-Nian [1 ,2 ,3 ]
机构：
[1] Xuzhou Med Univ, Inst Canc, 84 West Huaihai Rd, Xuzhou 221002, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Jiangsu Ctr Collaborat & Innovat Canc Biotherapy, Xuzhou 221002, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Ctr Clin Oncol, Affiliated Hosp, Xuzhou 221002, Jiangsu, Peoples R China
[4] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Zhejiang, Peoples R China
[5] Xuzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp, Xuzhou 221002, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2018年 / 14卷 / 14期
基金：
中国国家自然科学基金;
关键词：
cancer; long non-coding RNA; Wnt/beta-catenin signaling pathway; LONG NONCODING RNA; SQUAMOUS-CELL CARCINOMA; COLORECTAL-CANCER; GASTRIC-CANCER; LUNG-CANCER; PROMOTES PROLIFERATION; BLADDER-CANCER; POOR-PROGNOSIS; CISPLATIN RESISTANCE; DOWN-REGULATION;
D O I：
10.7150/ijbs.27977
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long noncoding RNAs (lncRNAs), with length of more than 200 nucleotides, are not translated into proteins but involved in multiple diverse diseases, especially tumorigenesis. The dysregulation of lncRNAs greatly contributes to the progression of various tumors through specific signaling pathways, including Wnt/beta-catenin signaling pathway, which is associated with malignant features of tumors. The interactions between lncRNAs, which have specific expression characteristics in diverse cancer tissues, and Wnt/beta-catenin signaling pathway, exhibit potential as novel biomarkers and therapeutic targets. In this review, we aim to present research findings on the roles of Wnt pathway-related lncRNAs and their effects on Wnt/beta-catenin signaling to regulate tumorigenesis in different cancer types. Results may be used as basis to develop or improve strategies for treatment of different carcinomas.
引用
收藏
页码：2003 / 2011
页数：9
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