Effects of β-Sitosteryl Sulfate on the Properties of DPPC Liposomes

被引：9
作者：
Kafle, Ananda [1 ]
Akamatsu, Masaaki [1 ]
Bhadani, Avinash [2 ]
Sakai, Kenichi [1 ]
Kaise, Chihiro [3 ]
Kaneko, Teruhisa [3 ]
Sakai, Hideki [1 ]
机构：
[1] Tokyo Univ Sci, Fac Sci & Technol, Dept Pure & Appl Chem, 2641 Yamazaki, Noda, Chiba 2788510, Japan
[2] Tokyo Univ Sci, Res Inst Sci & Technol, 2641 Yamazaki, Noda, Chiba 2788510, Japan
[3] LVMC Inc, Toshima Ku, Komagome 7-14-3, Tokyo 1700003, Japan
来源：
JOURNAL OF OLEO SCIENCE | 2018年 / 67卷 / 12期
关键词：
beta-sitosteryl sulfate; hydrodynamic diameter; corrugation; zeta-potential; fluorescence anisotropy; LIPID VESICLES; PARTICLE-SIZE; CHOLESTEROL; STABILITY; DELIVERY; BEHAVIOR; DRUG; SYSTEMS;
D O I：
10.5650/jos.ess18147
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The effect of beta-sitosteryl sulfate (PSO4) on the liposomal size, stability, fluidity, and dispersibility of DPPC liposomes prepared by vortex mixing, bath-sonication, and probe-sonication has been studied. PSO4 significantly decreases the particle size of the multilamellar liposomes (MLVs). The sizes of the vortex-mixed and the bath-sonicated liposomes vary as a function of PSO(4 )concentration. On the other hand, PSO(4 )has only little effect on the particle sizes of probe sonicated liposomes. In some cases, the liposomal stability at higher PSO(4 )concentrations depends on the preparation method. PSO(4 )improves the dispersihility of the DPPC liposomes and enhances their hydration. It also increases the fluidity of the liposomes prepared by each method. Our results suggest that liposomes consisting of DPPC and PSO4 can be suitable as a cosmetic or pharmaceutical ingredient for the effective delivery of the active components into the body.
引用
收藏
页码：1511 / 1519
页数：9
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