Spontaneous remission of primary hyperparathyroidism

The diagnosis of primary hyperparathyroidism (pHPT) is characterized by the constellation of elevated plasma serum calcium levels and low serum anorganic phosphate associated with inadequately high blood concentrations of parathyroid hormone (PTH). Parathyroid adenomas are the main reason for this disorder and can frequently be detected by ultrasound examination. Surgical removal of the parathyroid adenoma is recommended in the case of primary hyperparathyroidism complicated by osteoporosis, hypercalciuria, nephrolithiasis, or impaired renal function. Here we present the case of a 68-year-old man with spontaneous remission of primary hyperparathyroidism two years after the diagnosis was established. The remission was documented by laboratory findings (normalisation of serum calcium and PTH levels) and by ultrasound examination that showed the disappearance of a cervical mass suggesting a parathyroid adenoma.