Breakthrough Fungal Infections in Patients With Leukemia Receiving Isavuconazole

被引：93
作者：
Rausch, Caitlin R. [1 ]
DiPippo, Adam J. [1 ]
Bose, Prithviraj [2 ]
Kontoyiannis, Dimitrios P. [3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Div Pharm, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA
来源：
CLINICAL INFECTIOUS DISEASES | 2018年 / 67卷 / 10期
关键词：
isavuconazole; breakthrough; invasive fungal infections; neutropenia; leukemia; VORICONAZOLE; PROPHYLAXIS; DISEASES;
D O I：
10.1093/cid/ciy406
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We retrospectively assessed breakthrough invasive fungal infections (b-IFIs) in 100 consecutive patients with leukemia receiving single-agent isavuconazole; 13 had documented b-IFIs (candidiasis in 6, mucormycosis in 4). All b-IFIs were observed in patients with prolonged neutropenia and active leukemia.
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收藏
页码：1610 / 1613
页数：4
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