Electroencephalogram-Based Complexity Measures as Predictors of Post-operative Neurocognitive Dysfunction

被引:13
作者
Acker, Leah [1 ,2 ]
Ha, Christine [2 ]
Zhou, Junhong [3 ,4 ]
Manor, Brad [3 ,4 ]
Giattino, Charles M. [5 ]
Roberts, Ken [5 ]
Berger, Miles [1 ,2 ]
Wright, Mary Cooter [1 ]
Colon-Emeric, Cathleen [2 ,6 ]
Devinney, Michael [1 ]
Au, Sandra [2 ]
Woldorff, Marty G. [5 ,7 ,8 ]
Lipsitz, Lewis A. [3 ,4 ]
Whitson, Heather E. [2 ,6 ,9 ]
机构
[1] Duke Univ, Sch Med, Dept Anesthesiol, Durham, NC USA
[2] Duke Univ, Sch Med, Duke Ctr Study Aging & Human Dev, Durham, NC USA
[3] Hebrew Senior Life & Harvard Med Sch, Hinda & Arthur Marcus Inst Aging Res, Boston, MA USA
[4] Beth Israel Deaconess Med Ctr, Dept Med, Div Gerontol, Boston, MA 02215 USA
[5] Duke Univ, Ctr Cognit Neurosci, Durham, NC USA
[6] Duke Univ, Sch Med, Dept Med, Div Geriatr Med, Durham, NC USA
[7] Duke Univ, Dept Psychiat, Durham, NC USA
[8] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA
[9] Durham VA Med Ctr, Geriatr Res Educ & Clin Ctr, Durham, NC USA
关键词
electroencephalogram (EEG); complexity; resilience; cognition; attention; anesthesia; delirium; perioperative medicine; ALZHEIMERS-DISEASE; BURST-SUPPRESSION; OLDER-ADULTS; DELIRIUM; EEG; BYPASS; DYNAMICS; TRIAL; ANESTHESIA; DECREASES;
D O I
10.3389/fnsys.2021.718769
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Physiologic signals such as the electroencephalogram (EEG) demonstrate irregular behaviors due to the interaction of multiple control processes operating over different time scales. The complexity of this behavior can be quantified using multi-scale entropy (MSE). High physiologic complexity denotes health, and a loss of complexity can predict adverse outcomes. Since postoperative delirium is particularly hard to predict, we investigated whether the complexity of preoperative and intraoperative frontal EEG signals could predict postoperative delirium and its endophenotype, inattention. To calculate MSE, the sample entropy of EEG recordings was computed at different time scales, then plotted against scale; complexity is the total area under the curve. MSE of frontal EEG recordings was computed in 50 patients >= age 60 before and during surgery. Average MSE was higher intra-operatively than pre-operatively (p = 0.0003). However, intraoperative EEG MSE was lower than preoperative MSE at smaller scales, but higher at larger scales (interaction p < 0.001), creating a crossover point where, by definition, preoperative, and intraoperative MSE curves met. Overall, EEG complexity was not associated with delirium or attention. In 42/50 patients with single crossover points, the scale at which the intraoperative and preoperative entropy curves crossed showed an inverse relationship with delirium-severity score change (Spearman rho = -0.31, p = 0.054). Thus, average EEG complexity increases intra-operatively in older adults, but is scale dependent. The scale at which preoperative and intraoperative complexity is equal (i.e., the crossover point) may predict delirium. Future studies should assess whether the crossover point represents changes in neural control mechanisms that predispose patients to postoperative delirium.
引用
收藏
页数:11
相关论文
共 53 条
  • [41] Intraoperative burst suppression is associated with postoperative delirium following cardiac surgery: a prospective, observational study
    Soehle, Martin
    Dittmann, Alexander
    Ellerkmann, Richard K.
    Baumgarten, Georg
    Putensen, Christian
    Guenther, Ulf
    [J]. BMC ANESTHESIOLOGY, 2015, 15
  • [42] Electroencephalography-Guided Anesthetic Delivery for Preventing Postoperative Delirium in Adults: An Updated Meta-analysis
    Sun, Yi
    Ye, Fan
    Wang, Jing
    Ai, Pan
    Wei, Changwei
    Wu, Anshi
    Xie, Wuxiang
    [J]. ANESTHESIA AND ANALGESIA, 2020, 131 (03) : 712 - 719
  • [43] Age-related variation in EEG complexity to photic stimulation: A multiscale entropy analysis
    Takahashi, Tetsuya
    Cho, Raymond Y.
    Murata, Tetsuhito
    Mizuno, Tomoyuki
    Kikuchi, Mitsuru
    Mizukami, Kimiko
    Kosaka, Hirotaka
    Takahashi, Koichi
    Wada, Yuji
    [J]. CLINICAL NEUROPHYSIOLOGY, 2009, 120 (03) : 476 - 483
  • [44] ADAPT-2: A Randomized Clinical Trial to Reduce Intraoperative EEG Suppression in Older Surgical Patients Undergoing Major Noncardiac Surgery
    Tang, Christopher J.
    Jin, Zhongnan
    Sands, Laura P.
    Pleasants, Devon
    Tabatabai, Sanam
    Hong, Yili
    Leung, Jacqueline M.
    [J]. ANESTHESIA AND ANALGESIA, 2020, 131 (04) : 1228 - 1236
  • [45] Predisposition for delirium and EEG characteristics
    van Montfort, S. J. T.
    van Dellen, E.
    Wattel, L. L.
    Kant, I. M. J.
    Numan, T.
    Stam, C. J.
    Slooter, A. J. C.
    [J]. CLINICAL NEUROPHYSIOLOGY, 2020, 131 (05) : 1051 - 1058
  • [46] A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM)
    Vasunilashorn, Sarinnapha M.
    Devinney, Michael J.
    Acker, Leah
    Jung, Yoojin
    Ngo, Long
    Cooter, Mary
    Huang, Richard
    Marcantonio, Edward R.
    Berger, Miles
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2020, 68 (08) : 1874 - 1876
  • [47] Multi-scale sample entropy of electroencephalography during sevoflurane anesthesia
    Wang, Yinghua
    Liang, Zhenhu
    Voss, Logan J.
    Sleigh, Jamie W.
    Li, Xiaoli
    [J]. JOURNAL OF CLINICAL MONITORING AND COMPUTING, 2014, 28 (04) : 409 - 417
  • [48] Complexity-Based Measures Inform Effects of Tai Chi Training on Standing Postural Control: Cross-Sectional and Randomized Trial Studies
    Wayne, Peter M.
    Gow, Brian J.
    Costa, Madalena D.
    Peng, C. -K.
    Lipsitz, Lewis A.
    Hausdorff, Jeffrey M.
    Davis, Roger B.
    Walsh, Jacquelyn N.
    Lough, Matthew
    Novak, Vera
    Yeh, Gloria Y.
    Ahn, Andrew C.
    Macklin, Eric A.
    Manor, Brad
    [J]. PLOS ONE, 2014, 9 (12):
  • [49] Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery The ENGAGES Randomized Clinical Trial
    Wildes, Troy S.
    Mickle, Angela M.
    Ben Abdallah, Arbi
    Maybrier, Hannah R.
    Oberhaus, Jordan
    Budelier, Thaddeus P.
    Kronzer, Alex
    McKinnon, Sherry L.
    Park, Daniel
    Torres, Brian A.
    Graetz, Thomas J.
    Emmert, Daniel A.
    Palanca, Ben J.
    Goswami, Shreya
    Jordan, Katherine
    Lin, Nan
    Fritz, Bradley A.
    Stevens, TraceyW.
    Jacobsohn, Eric
    Schmitt, Evam.
    Inouye, Sharon K.
    Stark, Susan
    Lenze, Eric J.
    Avidan, Michael S.
    Ben Abdallah, Arbi
    Apakama, Ginika
    Aranake-Chrisinger, Amrita
    Avidan, Michael S.
    Bolzenius, Jacob
    Budelier, Thaddeus P.
    Burton, Jamila
    Cui, Victoria
    Emmert, Daniel A.
    Fritz, Bradley A.
    Goswami, Shreya
    Graetz, Thomas J.
    Gupta, Shelly
    Jordan, Katherine
    Kronzer, Alex
    Maybrier, Hannah R.
    McKinnon, Sherry L.
    Mickle, Angela M.
    Muench, Maxwell R.
    Murphy, Matthew R.
    Oberhaus, Jordan
    Palanca, Ben J.
    Park, Daniel
    Patel, Aamil
    Spencer, JamesW.
    Stevens, Tracey W.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 321 (05): : 473 - 483
  • [50] The temporal dynamics of the effects in occipital cortex of visual-spatial selective attention
    Woldorff, MG
    Liotti, M
    Seabolt, M
    Busse, L
    Lancaster, JL
    Fox, PT
    [J]. COGNITIVE BRAIN RESEARCH, 2002, 15 (01): : 1 - 15