Rh(iii)-Catalyzed -fluoroalkenylation of N-nitrosoanilines with 2,2-difluorovinyl tosylates via C-H bond activation

被引：43

作者：

Tian, Miaomiao ^{[1
]}

Yang, Xifa ^{[2
]}

Zhang, Bo ^{[1
]}

Liu, Bingxian ^{[1
]}

Li, Xingwei ^{[1
,2
,3
]}

机构：

[1] Henan Normal Univ, Sch Chem & Chem Engn, Henan Key Lab Organ Funct Mol & Drug Innovat, Xinxiang 453007, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[3] Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710119, Shaanxi, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 23期

关键词：

ALPHA-FLUOROALKENYLATION; FLUORINE; ARENES; CATALYSIS; NITROSO; FUNCTIONALIZATIONS; PHARMACEUTICALS; FLUOROOLEFINS; INHIBITORS; INDOLES;

D O I：

10.1039/c8qo00947c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rh(iii)-Catalyzed -fluoroalkenylation of N-nitrosoanilines with 2,2-difluorovinyl tosylates has been realized. This reaction proceeded via chelation-assisted C-H activation, olefin insertion and -F elimination, leading to the synthesis of monofluoroalkenes with high Z-selectivity with respect to the olefin. This catalytic system is highly efficient over a broad range of substrates under mild and redox-neutral conditions.

引用

页码：3406 / 3409

页数：4

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