Rhodium-Catalyzed 1,4-Addition of Arylboronic Acids to 3-Benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Derivatives

被引：9

作者：

Croix, Cecile ^{[1
]}

Prie, Gildas ^{[1
]}

Chaulet, Charlotte ^{[1
]}

Viaud-Massuard, Marie-Claude ^{[1
]}

机构：

[1] Univ Tours, GICC UMR 7292, Equipe Innovat Mol & Therapeut 4, Labex SYNORG,Fac Pharm, F-37200 Tours, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 06期

关键词：

ASYMMETRIC CONJUGATE ADDITION; MICHAEL-TYPE ADDITION; ALPHA; BETA-ETHYLENIC COMPOUNDS; ENANTIOSELECTIVE SYNTHESIS; ARYLATIVE CYCLIZATION; ALIPHATIC-AMINES; HIGH-PERFORMANCE; DIENE; LIGANDS; 7-AZAINDOLES;

D O I：

10.1021/jo502784h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

7-Azaindoles are versatile building blocks, especially in medicinal chemistry, where they serve as bioisosteres of indoles or purines. Herein, we present a novel rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to 3-benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-ones, as these substrates are exocyclic methylene lactamyl Michael acceptors. Ten new original derivatives of 1H-pyrrolo[2,3-b]pyridin-2(3H)-one have been obtained.

引用

收藏

页码：3264 / 3269

页数：6

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