Dose-related vincristine-induced peripheral neuropathy with unexpected off-therapy worsening

被引：135
作者：
Verstappen, CCP
Koeppen, S
Heimans, JJ
Huijgens, PC
Scheulen, E
Strumberg, D
Kiburg, B
Postma, TJ
机构：
[1] VU Univ, Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands
[2] VU Univ, Med Ctr, Dept Hematol, NL-1007 MB Amsterdam, Netherlands
[3] Univ Hosp Essen, Dept Neurol, Essen, Germany
[4] Univ Hosp Essen, Dept Internal Med, Essen, Germany
来源：
NEUROLOGY | 2005年 / 64卷 / 06期
关键词：
D O I：
10.1212/01.WNL.0000154642.45474.28
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study describes the natural course of vincristine-induced peripheral neuropathy in patients with lymphoma (n = 114) receiving vincristine in two different dose intensities. Neuropathic changes were observed in both dose intensity groups, but the higher dose intensity group reported significantly more symptoms during therapy, whereas neurologic signs were significantly more prominent after a cumulative dose of 12 mg vincristine. Furthermore, off-therapy worsening of symptoms (24%) and signs (30%) occurred unexpectedly.
引用
收藏
页码：1076 / 1077
页数：2
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