The antiproliferative signalling of somatostatin in pituitary tumour cells involves inhibition of the PI3K/Akt survival pathway and upregulation of the tumour suppressor gene Zac1

被引:0
|
作者
Theodoropoulou, M [1 ]
Laupheimer, S [1 ]
Pagotto, U [1 ]
Stalla, GK [1 ]
机构
[1] Max Planck Inst Psychiat, Dept Endocrinol, D-80804 Munich, Germany
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:1
相关论文
共 50 条
  • [11] Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway
    Hao-Wei Cheng
    Yi-Fang Chen
    Jau-Min Wong
    Chia-Wei Weng
    Hsuan-Yu Chen
    Sung-Liang Yu
    Huei-Wen Chen
    Ang Yuan
    Jeremy J.W. Chen
    Journal of Experimental & Clinical Cancer Research, 36
  • [12] Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway
    Cheng, Hao-Wei
    Chen, Yi-Fang
    Wong, Jau-Min
    Weng, Chia-Wei
    Chen, Hsuan-Yu
    Yu, Sung-Liang
    Chen, Huei-Wen
    Yuan, Ang
    Chen, Jeremy J. W.
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2017, 36 : 1 - 13
  • [13] Inhibition of PLK4 might enhance the anti-tumour effect of bortezomib on glioblastoma via PTEN/PI3K/AKT/mTOR signalling pathway
    Wang, Jing
    Ren, Dengpeng
    Sun, Yan
    Xu, Chao
    Wang, Chunhong
    Cheng, Rui
    Wang, Lina
    Jia, Guijun
    Ren, Jinrui
    Ma, Jiuhong
    Tu, Yue
    Ji, Hongming
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (07) : 3931 - 3947
  • [14] Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells
    Langenbach, KJ
    Rando, TA
    MUSCLE & NERVE, 2002, 26 (05) : 644 - 653
  • [15] Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder
    Sun, Chih-Hao
    Chang, Yen-Hwa
    Pan, Chin-Chen
    HISTOPATHOLOGY, 2011, 58 (07) : 1054 - 1063
  • [16] Cyclophilin A as a downstream effector of PI3K/Akt signalling pathway in multiple myeloma cells
    Lin, Zuo-Lin
    Wu, Hsin-Jou
    Chen, Jin-An
    Lin, Kuo-Chih
    Hsu, Jung-Hsin
    CELL BIOCHEMISTRY AND FUNCTION, 2015, 33 (08) : 566 - 574
  • [17] Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells
    Chen, Jun
    Xia, Dan
    Luo, Jin-Dan
    Wang, Ping
    ASIAN JOURNAL OF ANDROLOGY, 2009, 11 (06) : 669 - 677
  • [19] Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression
    Theodoropoulou, M
    Zhang, J
    Laupheimer, S
    Paez-Pereda, M
    Erneux, C
    Florio, T
    Pagotto, U
    Stalla, GK
    CANCER RESEARCH, 2006, 66 (03) : 1576 - 1582
  • [20] Nerve growth factor-induced migration in oral and salivary gland tumour cells utilises the PI3K/Akt signalling pathway: Is there a link to perineural invasion?
    Alkhadar, Huda
    Macluskey, Michaelina
    White, Sharon
    Ellis, Ian
    JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2020, 49 (03) : 227 - 234