Modulators of Toll-Like Receptor (TLR) Signaling

被引：9
作者：
Spyvee, Mark [1 ]
Hawkins, Lynn D. [1 ]
Ishizaka, Sally T. [1 ]
机构：
[1] Eisai Inc, Frontier Prod Creat Unit, Andover, MA 01810 USA
来源：
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45 | 2010年 / 45卷
关键词：
PLASMACYTOID DENDRITIC CELL; DOUBLE-STRANDED-RNA; IRAK-4; INHIBITORS; STRUCTURAL BASIS; IMMUNOSTIMULATORY ACTIVITY; CRYSTAL-STRUCTURES; BACTERIAL-DNA; CPG-MOTIF; PART; ACTIVATION;
D O I：
10.1016/S0065-7743(10)45012-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：191 / +
页数：18
相关论文
共 109 条
[61]   Pivotal Advance:: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound [J].
Loiarro, Maria ;
Capolunghi, Federica ;
Fanto, Nicola ;
Gallo, Grazia ;
Campo, Silvia ;
Arseni, Brunilde ;
Carsetti, Rita ;
Carminati, Paolo ;
De Santis, Rita ;
Ruggiero, Vito ;
Sette, Claudio .
JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 82 (04) :801-810
[62]   Antiflagellin antibodies recognize the autoantigens Toll-Like Receptor 5 and Pals 1-associated tight junction protein and induce monocytes activation and increased intestinal permeability in Crohn's disease [J].
Lunardi, C. ;
Bason, C. ;
Dolcino, M. ;
Navone, R. ;
Simone, R. ;
Saverino, D. ;
Frulloni, L. ;
Tinazzi, E. ;
Peterlana, D. ;
Corrocher, R. ;
Puccetti, A. .
JOURNAL OF INTERNAL MEDICINE, 2009, 265 (02) :250-265
[63]  
Manzel L, 1999, J PHARMACOL EXP THER, V291, P1337
[64]   Toll-like receptors in systemic autoimmune disease [J].
Marshak-Rothstein, Ann .
NATURE REVIEWS IMMUNOLOGY, 2006, 6 (11) :823-835
[65]   Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors [J].
Matsushima, Norio ;
Tanaka, Takanori ;
Enkhbayar, Purevjav ;
Mikami, Tomoko ;
Taga, Masae ;
Yamada, Keiko ;
Kuroki, Yoshio .
BMC GENOMICS, 2007, 8 (1)
[66]  
McDonald W., 2009, Compositions of dengue viral proteins and methods of use, Patent No. [WO2009128949, 2009128949]
[67]   Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9 [J].
Means, TK ;
Latz, E ;
Hayashi, F ;
Murali, MR ;
Golenbock, DT ;
Luster, AD .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) :407-417
[68]   A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [J].
Medzhitov, R ;
PrestonHurlburt, P ;
Janeway, CA .
NATURE, 1997, 388 (6640) :394-397
[69]   Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells [J].
Muzio, M ;
Bosisio, D ;
Polentarutti, N ;
D'amico, G ;
Stoppacciaro, A ;
Mancinelli, R ;
van't Veer, C ;
Penton-Rol, G ;
Ruco, LP ;
Allavena, P ;
Mantovani, A .
JOURNAL OF IMMUNOLOGY, 2000, 164 (11) :5998-6004
[70]   Antibiotic treatment of cutaneous infections with Staphylococcus aureus in patients with atopic dermatitis: current antimicrobial resistances and susceptibilities [J].
Niebuhr, Margarete ;
Mai, Uwe ;
Kapp, Alexander ;
Werfel, Thomas .
EXPERIMENTAL DERMATOLOGY, 2008, 17 (11) :953-957
234567891011