Modulators of Toll-Like Receptor (TLR) Signaling

被引:8
作者
Spyvee, Mark [1 ]
Hawkins, Lynn D. [1 ]
Ishizaka, Sally T. [1 ]
机构
[1] Eisai Inc, Frontier Prod Creat Unit, Andover, MA 01810 USA
来源
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45 | 2010年 / 45卷
关键词
PLASMACYTOID DENDRITIC CELL; DOUBLE-STRANDED-RNA; IRAK-4; INHIBITORS; STRUCTURAL BASIS; IMMUNOSTIMULATORY ACTIVITY; CRYSTAL-STRUCTURES; BACTERIAL-DNA; CPG-MOTIF; PART; ACTIVATION;
D O I
10.1016/S0065-7743(10)45012-5
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:191 / +
页数:18
相关论文
共 109 条
[11]   New synthesis of glycolipid immunostimulants RC-529 and CRX-524 [J].
Bazin, HG ;
Bess, LS ;
Livesay, MT ;
Ryter, KT ;
Johnson, CL ;
Arnold, JS ;
Johnson, DA .
TETRAHEDRON LETTERS, 2006, 47 (13) :2087-2092
[12]   Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes [J].
Boulé, MW ;
Broughton, C ;
Mackay, F ;
Akira, S ;
Marshak-Rothstein, A ;
Rifkin, IR .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (12) :1631-1640
[13]   The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling [J].
Brinkmann, Melanie M. ;
Spooner, Eric ;
Hoebe, Kasper ;
Beutler, Bruce ;
Ploegh, Hidde L. ;
Kim, You-Me .
JOURNAL OF CELL BIOLOGY, 2007, 177 (02) :265-275
[14]   IRAK-4 inhibitors.: Part III:: A series of imidazo[1,2-a] pyridines [J].
Buckley, George M. ;
Fosbeary, Richard ;
Fraser, Joanne L. ;
Gowers, Lewis ;
Higueruelo, Alicia P. ;
James, Lynwen A. ;
Jenkins, Kerry ;
Mack, Stephen R. ;
Morgan, Trevor ;
Parry, David M. ;
Pitt, William R. ;
Rausch, Oliver ;
Richard, Marianna D. ;
Sabin, Verity .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (12) :3656-3660
[15]   IRAK-4 inhibitors.: Part II:: A structure-based assessment of imidazo[1,2-a]pyridine binding [J].
Buckley, George M. ;
Ceska, Thomas A. ;
Fraser, Joanne L. ;
Gowers, Lewis ;
Groom, Colin R. ;
Higueruelo, Alicia Perez ;
Jenkins, Kerry ;
Mack, Stephen R. ;
Morgan, Trevor ;
Parry, David M. ;
Pitt, William R. ;
Rausch, Oliver ;
Richard, Marianna D. ;
Sabin, Verity .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (11) :3291-3295
[16]   IRAK-4 inhibitors. Part 1: A series of amides [J].
Buckley, George M. ;
Gowers, Lewis ;
Higueruelo, Alicia Perez ;
Jenkins, Kerry ;
Mack, Stephen R. ;
Morgan, Trevor ;
Parry, David M. ;
Pitt, William R. ;
Rausch, Oliver ;
Richard, Marianna D. ;
Sabin, Verity ;
Fraser, Joanne L. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (11) :3211-3214
[17]   An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models [J].
Burdelya, Lyudmila G. ;
Krivokrysenko, Vadim I. ;
Tallant, Thomas C. ;
Strom, Evguenia ;
Gleiberman, Anatoly S. ;
Gupta, Damodar ;
Kurnasov, Oleg V. ;
Fort, Farrel L. ;
Osterman, Andrei L. ;
DiDonato, Joseph A. ;
Feinstein, Elena ;
Gudkov, Andrei V. .
SCIENCE, 2008, 320 (5873) :226-230
[18]  
CHOW J, 2004, Patent No. 200435447
[19]   Small Molecule Modulators of Toll-like Receptors [J].
Czarniecki, Michael .
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (21) :6621-6626
[20]   MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional toll/IL-1 receptor domain/BB-loop mimetics [J].
Davis, CN ;
Mann, E ;
Behrens, MM ;
Gaidarova, S ;
Rebek, M ;
Rebek, J ;
Bartfai, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :2953-2958