Modulators of Toll-Like Receptor (TLR) Signaling

被引:8
作者
Spyvee, Mark [1 ]
Hawkins, Lynn D. [1 ]
Ishizaka, Sally T. [1 ]
机构
[1] Eisai Inc, Frontier Prod Creat Unit, Andover, MA 01810 USA
来源
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45 | 2010年 / 45卷
关键词
PLASMACYTOID DENDRITIC CELL; DOUBLE-STRANDED-RNA; IRAK-4; INHIBITORS; STRUCTURAL BASIS; IMMUNOSTIMULATORY ACTIVITY; CRYSTAL-STRUCTURES; BACTERIAL-DNA; CPG-MOTIF; PART; ACTIVATION;
D O I
10.1016/S0065-7743(10)45012-5
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:191 / +
页数:18
相关论文
共 109 条
[1]   Phase I, randomized, double-blind trial of 7-allyl-8-oxoguanosine (loxoribine) in advanced cancer [J].
Agarwala, SS ;
Kirkwood, JM ;
Bryant, J .
CYTOKINES CELLULAR & MOLECULAR THERAPY, 2000, 6 (04) :171-176
[2]   Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].
Alexopoulou, L ;
Holt, AC ;
Medzhitov, R ;
Flavell, RA .
NATURE, 2001, 413 (6857) :732-738
[3]   Innate immunity for biodefense: A strategy whose time has come [J].
Amlie-Lefond, C ;
Paz, DA ;
Connelly, MP ;
Huffnagle, GB ;
Dunn, KS ;
Whelan, NT ;
Whelan, HT .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (06) :1334-1342
[4]   A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin [J].
Andersen-Nissen, Erica ;
Smith, Kelly D. ;
Bonneau, Richard ;
Strong, Roland K. ;
Aderem, Alan .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (02) :393-403
[5]  
[Anonymous], [No title captured], Patent No. 2008030579
[6]  
AUBIN E, 2009, Patent No. 2009130616
[7]   TLR4 links podocytes with the innate immune system to mediate glomerular injury [J].
Banas, Miriam C. ;
Banas, Bernhard ;
Hudkins, Kelly L. ;
Wietecha, Tomasz A. ;
Iyoda, Masayuki ;
Bock, Elisabeth ;
Hauser, Peter ;
Pippin, Jeffrey W. ;
Shankland, Stuart J. ;
Smith, Kelly D. ;
Stoelcker, Benjamin ;
Liu, Gang ;
Groene, Hermann-Josef ;
Kraemer, Bernhard K. ;
Alpers, Charles E. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (04) :704-713
[8]   A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses [J].
Bartfai, T ;
Behrens, MM ;
Gaidarova, S ;
Pemberton, J ;
Shivanyuk, A ;
Rebek, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) :7971-7976
[9]   Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition [J].
Bauer, S ;
Kirschning, CJ ;
Häcker, H ;
Redecke, V ;
Hausmann, S ;
Akira, S ;
Wagner, H ;
Lipford, GB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :9237-9242
[10]   The 'Ethereal' nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics [J].
Bazin, Helene G. ;
Murray, Tim J. ;
Bowen, William S. ;
Mozaffarian, Afsaneh ;
Fling, Steven P. ;
Bess, Laura S. ;
Livesay, Mark T. ;
Arnold, Jeffrey S. ;
Johnson, Craig L. ;
Ryter, Kendal T. ;
Cluff, Christopher W. ;
Evans, Jay T. ;
Johnson, David A. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (20) :5350-5354