Association of Serum 25-Hydroxyvitamin D Concentration with Breast Cancer Risk in Postmenopausal Women in the US

被引：8

作者：

Ganji, Vijay ^{[1
]}

Sukik, Layan ^{[1
]}

Hoque, Bushra ^{[1
]}

Boutefnouchet, Linda ^{[1
]}

Shi, Zumin ^{[1
]}

机构：

[1] Qatar Univ, QU Hlth, Coll Hlth Sci, Human Nutr Dept, POB 2713, Doha, Qatar

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 06期

关键词：

breast cancer; cancer; NHANES; National Health and Nutrition Examination Survey; postmenopausal women; serum 25(OH)D; United States; vitamin D; VITAMIN-D STATUS; D DEFICIENCY; PREVALENCE; DENSITY; LUNG;

D O I：

10.3390/jpm12060944

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

The association between serum 25-hydroxyvitamin D [25(OH)D] concentration and breast cancer risk in postmenopausal women is not well understood. The aim of this study was to investigate the association between serum 25(OH)D concentration and breast cancer in postmenopausal women in the United States using nationally representative sample surveys. We used the data from seven cycles of National Health and Nutrition Examination Surveys from 2001 to 2014. Participants were non-institutionalized postmenopausal women (n = 8108). In restricted cubic spline analysis, a significant, nonlinear, invert 'U' relationship was observed between serum 25(OH)D concentrations and breast cancer in postmenopausal women (p = 0.029). Overall, breast cancer risk was highest (OR = 1.5) between 70 nmol/L and 80 nmol/L of serum 25(OH)D concentration. Then after serum 25(OH)D 80 nmol/L concentration, the breast cancer risk declined. In multivariate-adjusted logistic regression, the risk of having breast cancer was significantly higher in serum 25(OH)D 75-<100 nmol/L category compared to the 25(OH)D < 30 nmol/L category [OR and 95% CI: 2.4 (1.4-4.0)]. In conclusion, serum vitamin D concentrations >= 100 nmol/L are associated with reduced risk of breast cancer in postmenopausal women. Controlled trials are required to verify if serum 25(OH)D >= 100 nmol/L offers protection against breast cancer in postmenopausal women.

引用

页数：14

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