Modulation of immunity to respiratory viral infection

被引：0

作者：

Shelgrove, Robert ^{[1
]}

Gwyer, Emily ^{[1
]}

Hussell, Traiy ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Kennedy Inst Rheumatol, London W6 8LH, England

来源：

FUTURE VIROLOGY | 2006年 / 1卷 / 04期

关键词：

antitumor necrosis factor; immune modulation; immunopathology; innate imprinting; lung; OX40; virus;

D O I：

10.2217/17460794.1.4.471

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Acute respiratory tract infections cause approximately 4 million deaths globally each year. Current strategies to combat these infections include vaccines and antiviral drugs. However, a significant proportion of the pathology and illness induced by respiratory viral infection is attributed to an excessive host immune response, rather than the cytopathic nature of the pathogen. Distinct respiratory viruses elicit common immune mediators and cells, which are subsequently the cause of pathology. Therefore, strategies that seek to attenuate the potency of the host's immune response may provide generic relief from multiple respiratory infections.

引用

页码：471 / 481

页数：11

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