Increased expression of CD81 is associated with poor prognosis of prostate cancer and increases the progression of prostate cancer cells in vitro

被引：21
作者：
Zhang, Yu [1 ]
Qian, Haining [1 ]
Xu, An [1 ]
Yang, Ganggang [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Urol, 1111 Xianxia Rd, Shanghai 200336, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2020年 / 19卷 / 01期
关键词：
CD81; prostate cancer; prognosis; progression; ESTRO-SIOG GUIDELINES; TETRASPANINS; METASTASIS; GENE; BIOMARKERS; PROTEIN;
D O I：
10.3892/etm.2019.8244
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
CD81, a member of the tetraspanin family, has been revealed to be upregulated and associated with prognosis in several types of cancer; however, this relationship has not been explored in prostate cancer. The present study aimed to investigate the prognostic significance and functional role of CD81 in prostate cancer. The expression of CD81 in prostate cancer tissues and cell lines was evaluated using qRT-PCR analysis. Kaplan-Meier survival analysis and Cox regression analysis were conducted to explore the prognostic significance of CD81. Cell experiments were used to explore the effects of CD81 on cell proliferation, migration, and invasion in prostate cell lines in vitro. The expression of CD81 was increased in both prostate cancer tissues and cell lines. Upregulation of CD81 was significantly associated with lymph node metastasis and TNM stage. Moreover, patients with high CD81 levels had poorer overall survival than those with lower levels. Additionally, tumor cell proliferation, migration, and invasion were inhibited by knockdown of CD81. The present results indicated that CD81 plays an oncogenic role in prostate cancer. Overexpression of CD81 may serve as a prognostic biomarker and therapeutic target and is involved in the progression of prostate cancer.
引用
收藏
页码：755 / 761
页数：7
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