In situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) for peripheral nerve interfaces

被引：22
作者：
Murbach, Jamie M. [1 ]
Currlin, Seth [2 ]
Widener, Adrienne [1 ]
Tong, Yuxin [3 ]
Chhatre, Shrirang [4 ]
Subramanian, Vivek [4 ]
Martin, David C. [4 ]
Johnson, Blake N. [3 ]
Otto, Kevin J. [1 ,5 ]
机构：
[1] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA
[2] Univ Florida, Dept Neurosci, Gainesville, FL 32611 USA
[3] Virginia Tech, Dept Ind & Syst Engn, Blacksburg, VA 24061 USA
[4] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA
[5] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA
来源：
MRS COMMUNICATIONS | 2018年 / 8卷 / 03期
基金：
美国国家科学基金会;
关键词：
CONDUCTING POLYMERS; NEURAL INTERFACES; MICROELECTRODE ARRAYS; ELECTRODES; VIVO; STIMULATION; RECORDINGS; DEPOSITION; POLYIMIDE; TISSUE;
D O I：
10.1557/mrc.2018.138
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The goal of this study was to perform in situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) in peripheral nerves to create a soft, precisely located injectable conductive polymer electrode for bi-directional communication. Intraneural PEDOT polymerization was performed to target both outer and inner fascicles via custom fabricated 3D printed cuff electrodes and monomer injection strategies using a combination electrode-cannula system. Electrochemistry, histology. and laser light sheet microscopy revealed the presence of PEDOT at specified locations inside of peripheral nerve. This work demonstrates the potential for using in situ PEDOT electrodeposition as an injectable electrode for recording and stimulation of peripheral nerves.
引用
收藏
页码：1043 / 1049
页数：7
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