Synthesis and Characterization of a "Turn-On" photoCORM for Trackable CO Delivery to Biological Targets

被引：77

作者：

Carrington, Samantha J. ^{[1
]}

Chakraborty, Indranil ^{[1
]}

Bernard, Jenna M. L. ^{[2
]}

Mascharak, Pradip K. ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2014年 / 5卷 / 12期

基金：

美国国家科学基金会;

关键词：

Carbon monoxide; photoactive metal carbonyls; CO delivery; apoptosis; fluorescence tracking; METAL-CARBONYL-COMPLEXES; DESIGN STRATEGIES; VISIBLE-LIGHT; MONOXIDE; MOLECULES; RELEASE; CELLS;

D O I：

10.1021/ml500399r

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A designed photoactive CO releasing molecule (photoCORM), namely, fac-[MnBr(CO)(3)(pbt)] (1, pbt = 2-(2-pyridyl)benzothiazole), promotes CO-induced death of MDA-MB-231 human breast cancer cells upon illumination with broadband visible light. The CO release from this photoCORM can be tracked by rise in fluorescence within the cellular matrix due to deligation of the pbt ligand. The results of this study suggest the potential of 1 in eradication of cancer cells through CO delivery.

引用

页码：1324 / 1328

页数：5

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