Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy

被引：32

作者：

Pucci, Olivia ^{[1
]}

Toronov, Vladislav ^{[1
]}

St Lawrence, Keith ^{[2
,3
]}

机构：

[1] Ryerson Univ, Dept Phys, Toronto, ON M5B 2K3, Canada

[2] Lawson Hlth Res Inst, Imaging Div, London, ON N6A 4V2, Canada

[3] Univ Western Ontario, Dept Med Biophys, London, ON N6A 4V2, Canada

来源：

APPLIED OPTICS | 2010年 / 49卷 / 32期

基金：

加拿大自然科学与工程研究理事会;

关键词：

NONINVASIVE DETERMINATION; TURBID MEDIA; BRAIN; LIGHT; LAYER; OXYGENATION; ABSORPTION; SCATTERING; WATER;

D O I：

10.1364/AO.49.006324

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present the development of a continuous-wave method of quantifying the optical properties of a two-layered model of the human head using a broadband spectral approach. Absolute absorption and scattering properties of the upper and lower layers of phantoms with known optical properties were reconstructed from steady-state multi-distance measurements by performing differential fit analysis of the near-infrared reflectance spectrum between 700 and 1000 nm. From spectra acquired at 10, 20, and 30 mm, the concentration of a chromophore in the bottom layer was determined within an error of 10% in the presence of a 15 mm thick top layer. These results demonstrate that our method was able to determine the optical properties of the lower layer, which represents brain, with acceptable error at specific source-detector distances. (C) 2010 Optical Society of America

引用

页码：6324 / 6332

页数：9

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