Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice

被引:23
作者
Bedarida, Tatiana [1 ,2 ]
Baron, Stephanie [2 ,3 ]
Vibert, Francoise [2 ,4 ]
Ayer, Audrey [5 ]
Henrion, Daniel [5 ]
Thioulouse, Elizabeth [6 ]
Marchiol, Carmen [2 ,7 ]
Beaudeux, Jean-Louis [2 ,4 ,8 ]
Cottart, Charles-Henry [2 ,8 ]
Nivet-Antoine, Valerie [1 ,2 ,9 ]
机构
[1] Fac Pharm, INSERM, UMRS 1140, Paris, France
[2] Paris Descartes Univ, Sorbonne Paris Cite, Paris, France
[3] Georges Pompidou European Hosp, AP HP, Dept Physiol, Paris, France
[4] Fac Pharm, UMR S 1139, Paris, France
[5] Univ Angers, INSERM, U1083, CNRS,UMR 6214, Angers, France
[6] Trousseau Hosp, AP HP, Biochem Lab, Paris, France
[7] Cochin Inst, U1016, PIPA, Paris, France
[8] Hop Necker Enfants Malad, AP HP, Clin Biochem, Paris, France
[9] Georges Pompidou European Hosp, AP HP, Dept Biochem, Paris, France
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2016年 / 71卷 / 06期
关键词
Resveratrol; Arterial aging; Oxidative stress; Thioredoxin-interacting protein; Glucose intolerance; THIOREDOXIN-INTERACTING-PROTEIN; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; TRANS-RESVERATROL; PLASMA-MEMBRANE; GLUCOSE; GENE; METABOLISM; DELETION; ADIPOGENESIS;
D O I
10.1093/gerona/glv071
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Aging leads to a high prevalence of glucose intolerance and cardiovascular diseases, with oxidative stress playing a potential role. Resveratrol has shown promising effects on glucose tolerance and tends to improve endothelial function in elderly patients. Thioredoxin-interacting protein (TXNIP) was recently proposed as a potential link connecting glucose metabolism to oxidative stress. Here, we investigated the resveratrol-induced improvement of arterial aging phenotype in old mice and the expression of aortic TXNIP. Using an in vivo model of old mice with or without 3-month resveratrol treatment, we investigated the effects of resveratrol on age-related impairments from a cardiovascular Doppler analysis, to a molecular level, by studying inflammation and oxidative stress factors. We found a dual effect of resveratrol, with a decrease of age-related glucose intolerance and oxidative stress imbalance leading to reduced matrix remodeling that forestalls arterial aging phenotype in terms of intima-media thickness and arterial distensibility. These results provide the first evidence that aortic TXNIP mRNA and protein nuclear expressions are increased in the arterial aging and decreased by resveratrol treatment. In conclusion, we demonstrated that resveratrol helped to restore several aging impaired processes in old mice, with a decrease of aortic TXNIP mRNA and protein nuclear expressions.
引用
收藏
页码:720 / 729
页数:10
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