Global aging and the brain

被引：13
作者：
Kirkwood, Thomas B. L. [1 ]
机构：
[1] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
来源：
NUTRITION REVIEWS | 2010年 / 68卷 / 12期
基金：
英国医学研究理事会;
关键词：
aging; brain aging; longevity; mental capital; neurodegeneration; senescence; CAENORHABDITIS-ELEGANS; LIFE-SPAN; NEURONS;
D O I：
10.1111/j.1753-4887.2010.00343.x
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Intrinsic aging of the brain and its relationship to age-related neurodegenerative diseases need to be understood as part of global aging, which results from gradual accumulation of a variety of kinds of cellular and molecular damage. While certain kinds of molecular lesions are particularly associated with specific diseases, there is substantial overlap between the pathways causing disease and those contributing to global aging. Growing evidence indicates that the global aging process is more malleable than used to be thought. This needs to be taken into account in efforts to improve health and retention of mental capital across the life course.
引用
收藏
页码：S65 / S69
页数：5
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