Characteristics and prognosis of glomangiopericytomas: A systematic review

Background: Glomangiopericytoma belongs to the category of borderline/low-malignant-potential tumors of the sinonasal tract, but no studies about prognosis have been reported. Methods: To define the characteristics of glomangiopericytoma and to identify its prognostic factors, a systematic review was performed. A total of 337 cases of glomangiopericytomas were analyzed. Results: Patients with glomangiopericytoma demonstrating resection margin involvement and receiving radiotherapy/chemotherapy had a significantly worse disease-free survival time (P=.014 and.006, respectively). Patients with glomangiopericytoma had a tendency toward longer overall survival when they were diagnosed at a younger age (<= 60 years; P=.001), did not demonstrate marginal involvement (P=.032), recurrence/metastasis (P=.002), or radiotherapy/chemotherapy (P=.010), and had a right-sided tumor (P<. 001), actin-immunopositivity (P<. 001), and CD34-/BCL2-immunonegativities (P=.002 and.019, respectively). By multivariate analysis, actin (P<. 001) and CD34 (P=.002) immunostaining were significantly related to the overall survival of patients with glomangiopericytoma. Conclusion: Actin and CD34 immunostaining could be used as independent prognostic indicators of glomangiopericytomas.