Characteristics and prognosis of glomangiopericytomas: A systematic review

被引:21
作者
Park, Eun Su [1 ]
Kim, Jiyoung [1 ]
Jun, Sun-Young [1 ]
机构
[1] Catholic Univ Korea, Coll Med, Incheon St Marys Hosp, Dept Pathol, 56 Dongsu Ro, Incheon 21431, South Korea
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 09期
关键词
glomangiopericytoma; glomus tumor; hemangiopericytoma; sinonasal tumor; solitary fibrous tumor; SOLITARY FIBROUS TUMOR; SINONASAL-TYPE HEMANGIOPERICYTOMA; NASAL CAVITY; GLOMUS TUMOR; BETA-CATENIN; MAXILLARY SINUS; GLOMANGIOMA; HEAD; DIAGNOSIS; NOSE;
D O I
10.1002/hed.24818
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background: Glomangiopericytoma belongs to the category of borderline/low-malignant-potential tumors of the sinonasal tract, but no studies about prognosis have been reported. Methods: To define the characteristics of glomangiopericytoma and to identify its prognostic factors, a systematic review was performed. A total of 337 cases of glomangiopericytomas were analyzed. Results: Patients with glomangiopericytoma demonstrating resection margin involvement and receiving radiotherapy/chemotherapy had a significantly worse disease-free survival time (P=.014 and.006, respectively). Patients with glomangiopericytoma had a tendency toward longer overall survival when they were diagnosed at a younger age (<= 60 years; P=.001), did not demonstrate marginal involvement (P=.032), recurrence/metastasis (P=.002), or radiotherapy/chemotherapy (P=.010), and had a right-sided tumor (P<. 001), actin-immunopositivity (P<. 001), and CD34-/BCL2-immunonegativities (P=.002 and.019, respectively). By multivariate analysis, actin (P<. 001) and CD34 (P=.002) immunostaining were significantly related to the overall survival of patients with glomangiopericytoma. Conclusion: Actin and CD34 immunostaining could be used as independent prognostic indicators of glomangiopericytomas.
引用
收藏
页码:1897 / 1909
页数:13
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