Last Decade of Unconventional Methodologies for the Synthesis of Substituted Benzofurans

被引：46
作者：
Chiummiento, Lucia [1 ]
D'Orsi, Rosarita [1 ]
Funicello, Maria [1 ]
Lupattelli, Paolo [1 ]
机构：
[1] Dept Sci, Via Ateneo Lucano 10, I-85100 Potenza, Italy
来源：
MOLECULES | 2020年 / 25卷 / 10期
关键词：
synthesis of benzofurans; intra-molecular approach; inter-molecular approach; ONE-POT SYNTHESIS; SONOGASHIRA COUPLING-CYCLIZATION; PALLADIUM-CATALYZED SYNTHESIS; ALIPHATIC NITRILES SYNTHESIS; ALKYL ARYL KETONES; ONE-STEP SYNTHESIS; 2,3-DISUBSTITUTED BENZOFURANS; FUNCTIONALIZED BENZOFURANS; DIVERGENT SYNTHESIS; NATURAL-PRODUCTS;
D O I：
10.3390/molecules25102327
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review describes the progress of the last decade on the synthesis of substituted benzofurans, which are useful scaffolds for the synthesis of numerous natural products and pharmaceuticals. In particular, new intramolecular and intermolecular C-C and/or C-O bond-forming processes, with transition-metal catalysis or metal-free are summarized. (1) Introduction. (2) Ring generation via intramolecular cyclization. (2.1) C7a-O bond formation: (route a). (2.2) O-C2 bond formation: (route b). (2.3) C2-C3 bond formation: (route c). (2.4) C3-C3a bond formation: (route d). (3) Ring generation via intermolecular cyclization. (3.1) C7a-O and C3-C3a bond formation (route a + d). (3.2) O-C2 and C2-C3 bond formation: (route b + c). (3.3) O-C2 and C3-C3a bond formation: (route b + d). (4) Benzannulation. (5) Conclusion.
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页数：52
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